Jahan Israt, Islam Md Aminul, Harun-Ur-Rashid Mohammad, Sultana Gazi Nurun Nahar
Genetic Engineering and Biotechnology Research Laboratory (GEBRL), Centre for Advanced Research in Sciences (CARS), University of Dhaka, Dhaka, 1000, Bangladesh.
Department of Chemistry, International University of Business Agriculture and Technology (IUBAT), Dhaka, 1230, Bangladesh.
Heliyon. 2024 Oct 23;10(21):e39680. doi: 10.1016/j.heliyon.2024.e39680. eCollection 2024 Nov 15.
Cancer remains a leading cause of morbidity and mortality worldwide, necessitating ongoing exploration of effective prevention strategies. Micronutrients, vital for maintaining cellular health, offer promising avenues for cancer prevention. This review delineates the critical roles of micronutrients in cancer prevention, elucidating their mechanisms at the cellular level. Focusing on essential vitamins and minerals like Vitamins A, C, D, E, selenium, and zinc, we explore their profound effects on fundamental cellular processes such as DNA repair, oxidative stress regulation, cellular proliferation, and immune surveillance. These nutrients, characterized by their antioxidative, anti-inflammatory, and immune-enhancing properties, have shown potential in reducing the risk of cancer. The article synthesizes outcomes from a broad spectrum of clinical trials, epidemiological studies, and systematic reviews to evaluate the efficacy of micronutrients in thwarting cancer development. This critical analysis explores significant trials, addresses controversies in nutrient efficacy, and highlights the implications for clinical practice and public health policy. The review underscores the importance of integrating nutritional strategies into comprehensive cancer prevention frameworks and suggests directions for future research to optimize the preventive potentials of micronutrients.
癌症仍然是全球发病和死亡的主要原因，因此有必要不断探索有效的预防策略。微量营养素对维持细胞健康至关重要，为癌症预防提供了有前景的途径。本综述阐述了微量营养素在癌症预防中的关键作用，在细胞水平上阐明了它们的作用机制。聚焦于维生素A、C、D、E、硒和锌等必需维生素和矿物质，我们探讨了它们对DNA修复、氧化应激调节、细胞增殖和免疫监视等基本细胞过程的深远影响。这些营养素具有抗氧化、抗炎和增强免疫的特性，已显示出降低癌症风险的潜力。本文综合了广泛的临床试验、流行病学研究和系统评价的结果，以评估微量营养素在阻止癌症发展方面的功效。这一批判性分析探讨了重要试验，解决了营养素功效方面的争议，并强调了对临床实践和公共卫生政策的影响。该综述强调了将营养策略纳入全面癌症预防框架的重要性，并为未来研究指明方向，以优化微量营养素的预防潜力。
