Cancer J. 2023;29(2):89-97. doi: 10.1097/PPO.0000000000000649.
Diet plays critical roles in defining our immune responses, microbiome, and progression of human diseases. With recent progress in sequencing and bioinformatic techniques, increasing evidence indicates the importance of diet-microbial interactions in cancer development and therapeutic outcome. Here, we focus on the epidemiological studies on diet-bacterial interactions in the colon cancer. We also review the progress of mechanistic studies using the experimental models. Finally, we discuss the limits and future directions in the research of microbiome and diet in cancer development and therapeutic outcome. Now, it is clear that microbes can influence the efficacy of cancer therapies. These research results open new possibilities for the diagnosis, prevention, and treatment of cancer. However, there are still big gaps to apply these new findings to the clinical practice.
饮食在确定我们的免疫反应、微生物组和人类疾病的进展方面起着关键作用。随着测序和生物信息学技术的最新进展，越来越多的证据表明饮食与微生物的相互作用对癌症的发生和治疗结果具有重要意义。在这里，我们重点讨论了关于结肠癌中饮食与细菌相互作用的流行病学研究。我们还回顾了使用实验模型进行的机制研究的进展。最后，我们讨论了在癌症发生和治疗结果中研究微生物组和饮食的局限性和未来方向。现在，很明显微生物可以影响癌症治疗的效果。这些研究结果为癌症的诊断、预防和治疗开辟了新的可能性。然而，要将这些新发现应用于临床实践，仍然存在很大的差距。
