Role of bar press-related neurons in the dorsolateral prefrontal cortex during task performance by monkey.

Extracellular single neuron activity of the dorsolateral prefrontal cortex (DL) was recorded in the monkey, during bar pressing for reward. The bar press-related neurons which exhibited excitation or inhibition during the bar press period were found to be scattered diffusely in the DL. Activity changes that arose during the bar press period also appeared when the experimenter pressed the bar for the monkey. When delivery of food was delayed for a random time after cue tone on, bar press responses were still confined to the bar press period and did not extend beyond the cue tone. These results, together with the lesion studies, suggest that bar press-related neurons are involved in the animal's concentration during the bar press period.