Zeisler Zachary R, Love Marques, Rutishauser Ueli, Stoll Frederic M, Rudebeck Peter H
Nash Family Department of Neuroscience, Lipschultz Center for Cognitive Neuroscience, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029.
Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
bioRxiv. 2024 Nov 1:2024.10.30.621133. doi: 10.1101/2024.10.30.621133.
The intrinsic timescales of single neurons are thought to be hierarchically organized across the cortex. This conclusion, however, is primarily based on analyses of neural responses from macaques. Whether hierarchical variation in timescales is a general brain organizing principle across mammals remains unclear. Here we took a cross-species approach and estimated neuronal timescales of thousands of single neurons recorded across multiple areas in mice, monkeys, and humans using a task-agnostic method. We identify largely consistent hierarchies of timescales in frontal and limbic regions across species: hippocampus had the shortest timescale whereas anterior cingulate cortex had the longest. Within this scheme, variability across species was found, most notably in amygdala and orbitofrontal cortex. We show that variation in timescales is not simply related to differences in spiking statistics nor the result of cytoarchitectonic features such as cortical granularity. Thus, hierarchically organized timescales are a consistent organizing principle across species and appear to be related to a combination of intrinsic and extrinsic factors.
单个神经元的固有时间尺度被认为在整个皮层中呈层次结构组织。然而，这一结论主要基于对猕猴神经反应的分析。时间尺度的层次变化是否是所有哺乳动物普遍的大脑组织原则仍不清楚。在这里，我们采用跨物种方法，使用一种与任务无关的方法，估计了在小鼠、猴子和人类多个区域记录的数千个单个神经元的时间尺度。我们发现跨物种的额叶和边缘区域在很大程度上具有一致的时间尺度层次结构：海马体的时间尺度最短，而前扣带回皮层的时间尺度最长。在这个框架内，发现了物种间的变异性，最显著的是在杏仁核和眶额皮层。我们表明，时间尺度的变化不仅仅与放电统计的差异有关，也不是细胞结构特征（如皮质颗粒度）的结果。因此，层次结构组织的时间尺度是跨物种一致的组织原则，并且似乎与内在和外在因素的组合有关。
