Zeisler Zachary R, Love Marques, Rutishauser Ueli, Stoll Frederic M, Rudebeck Peter H
Nash Family Department of Neuroscience, Lipschultz Center for Cognitive Neuroscience, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029
Nash Family Department of Neuroscience, Lipschultz Center for Cognitive Neuroscience, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
J Neurosci. 2025 May 7;45(19):e2155242025. doi: 10.1523/JNEUROSCI.2155-24.2025.
The intrinsic timescales of single neurons are thought to be hierarchically organized across the cortex, but whether hierarchical variation in timescales is a general brain organizing principle across mammalian species remains unclear. Here, we took a cross-species approach and estimated neuronal timescales of thousands of single neurons recorded across frontal cortex, amygdala, and hippocampus in mice, monkeys, and humans of both sexes using a task-agnostic method. We identify largely consistent hierarchies of timescales in frontal and limbic regions across species: hippocampus had the shortest timescale whereas anterior cingulate cortex had the longest. Within this scheme, variability across species was found, most notably in amygdala and orbitofrontal cortex. We show that variation in timescales is not simply related to differences in spiking statistics nor the result of cytoarchitectonic features such as cortical granularity. Thus, hierarchically organized timescales are a consistent organizing principle across species and appear to be related to a combination of intrinsic and extrinsic factors.
单个神经元的内在时间尺度被认为在整个皮层中是分层组织的，但时间尺度的分层变化是否是跨哺乳动物物种的普遍大脑组织原则仍不清楚。在这里，我们采用了跨物种方法，使用一种与任务无关的方法，估计了在小鼠、猴子和人类两性的额叶皮层、杏仁核和海马体中记录的数千个单个神经元的神经元时间尺度。我们发现跨物种的额叶和边缘区域在时间尺度上有很大程度一致的层级：海马体的时间尺度最短，而前扣带回皮层的时间尺度最长。在这个框架内，发现了物种间的变异性，最明显的是在杏仁核和眶额皮层。我们表明，时间尺度的变化不仅仅与放电统计的差异有关，也不是细胞结构特征（如皮层颗粒度）的结果。因此，分层组织的时间尺度是跨物种的一致组织原则，并且似乎与内在和外在因素的组合有关。
