普通人群中儿童脑形态与强迫症状的纵向关系
The Longitudinal Relationship Between Brain Morphology and Obsessive-Compulsive Symptoms in Children From the General Population.
作者信息
Weeland Cees J, Vriend Chris, Tiemeier Henning, van den Heuvel Odile A, White Tonya
机构信息
Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Amsterdam Neuroscience, Compulsivity, Impulsivity & Attention program, Amsterdam, the Netherlands.
出版信息
JAACAP Open. 2023 Dec 25;2(2):126-134. doi: 10.1016/j.jaacop.2023.11.003. eCollection 2024 Jun.
OBJECTIVE
Cross-sectional studies in children with obsessive-compulsive disorder (OCD) have found larger thalamic volume, which is not found at later ages. We previously found that 9- to 12-year-old children from the general population with clinical-level obsessive-compulsive symptoms (OCS) also have a larger thalamus. Thus, using a longitudinal design, we studied the relationship among thalamic volume, cortical maturation, and the course of OCS.
METHOD
Children from the population-based Generation R Study underwent 1 or 2 (N = 2,552) magnetic resonance imaging (MRI) scans between the age of 9 and 16 years (baseline 9-12 years, follow-up 13-16 years). OCS were assessed with the Short Obsessive-Compulsive Disorder Screener (SOCS) questionnaire using both continuous and clinical cut-off measures to identify children with "probable OCD." We applied linear regression models to investigate the cross-sectional relationship between brain morphology and OCS at age 13 to 16 years. Linear mixed-effect models were fitted to model the bidirectional longitudinal relationship between thalamus and OCS and the thalamus and cortical morphology.
RESULTS
Thalamic volume was not different between probable OCD cases and controls at age 13 to 16 years. Higher baseline thalamic volume predicted a relative persistence of OCS and a flatter slope of thinning in 12 cortical regions.
CONCLUSION
Larger thalamic volume may be a subtle biomarker for persistent OCS symptoms. The persistence of OCS and cortical thickness in relation to earlier larger thalamic volume may reflect being at an earlier stage in neurodevelopment. Longitudinal designs with repeated multimodal brain imaging are warranted to improve our understanding of the neurodevelopmental processes underlying OCS and OCD.
STUDY PREREGISTRATION INFORMATION
Relationship between obsessive-compulsive symptoms and brain morphology in school-aged children in the general population; https://osf.io/; y6vs2.
目的
对患有强迫症（OCD）的儿童进行的横断面研究发现丘脑体积较大，而在年龄稍大时未发现这种情况。我们之前发现，来自普通人群的9至12岁有临床水平强迫症状（OCS）的儿童丘脑也较大。因此，我们采用纵向设计，研究丘脑体积、皮质成熟度与OCS病程之间的关系。
方法
基于人群的Generation R研究中的儿童在9至16岁之间接受了1次或2次（N = 2552）磁共振成像（MRI）扫描（基线年龄9至12岁，随访年龄13至16岁）。使用简短强迫症筛查问卷（SOCS）通过连续和临床临界值测量来评估OCS，以识别“可能患有OCD”的儿童。我们应用线性回归模型研究13至16岁时脑形态与OCS之间的横断面关系。采用线性混合效应模型来模拟丘脑与OCS之间以及丘脑与皮质形态之间的双向纵向关系。
结果
13至16岁时，可能患有OCD的病例与对照组之间的丘脑体积没有差异。较高的基线丘脑体积预示着OCS相对持续存在，并且12个皮质区域变薄的斜率较平缓。
结论
较大的丘脑体积可能是持续性OCS症状的一个微妙生物标志物。OCS的持续存在以及与早期较大丘脑体积相关的皮质厚度可能反映出处于神经发育的早期阶段。有必要采用重复多模态脑成像的纵向设计来增进我们对OCS和OCD潜在神经发育过程的理解。
研究预注册信息
普通人群中学龄儿童强迫症状与脑形态的关系；https://osf.io/；y6vs2。
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