Human is sufficient to stimulate tubular lysosomes and extend healthspan in well-fed .

Small VCP Interacting Protein (SVIP) is essential for maintaining a unique form of tubular lysosomes (TLs) in . Although do not have an annotated ortholog, expression of in the intestine induces TLs constitutively, increases autophagic activity, and extends healthspan. Here, we find that expression of the human ortholog of in the gut causes similar physiological and phenotypic effects as , albeit some effects were less pronounced. These results demonstrate that human can induce functional TLs in but may be a weaker allele compared to .