Gill Joshua P, DeLeo Kathryn R, Bohnert K Adam, Johnson Alyssa E
Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States.
MicroPubl Biol. 2024 Nov 1;2024. doi: 10.17912/micropub.biology.001379. eCollection 2024.
Small VCP Interacting Protein (SVIP) is essential for maintaining a unique form of tubular lysosomes (TLs) in . Although do not have an annotated ortholog, expression of in the intestine induces TLs constitutively, increases autophagic activity, and extends healthspan. Here, we find that expression of the human ortholog of in the gut causes similar physiological and phenotypic effects as , albeit some effects were less pronounced. These results demonstrate that human can induce functional TLs in but may be a weaker allele compared to .
小VCP相互作用蛋白（SVIP）对于维持[具体生物]中一种独特形式的管状溶酶体（TLs）至关重要。尽管[具体生物]没有注释的直系同源物，但[具体生物]中[具体基因]的表达可组成性地诱导TLs，增加自噬活性，并延长健康寿命。在这里，我们发现人类[具体基因]直系同源物在[具体生物]肠道中的表达会引起与[具体基因]相似的生理和表型效应，尽管有些效应不太明显。这些结果表明，人类[具体基因]可以在[具体生物]中诱导功能性TLs，但与[具体基因]相比可能是一个较弱的等位基因。
