抗氧化剂摄入的饮食来源与非酒精性脂肪性肝病的关联：2017 - 2020年美国国家健康与营养检查调查及孟德尔随机化研究 - Suppr

Associations of dietary sources of antioxidant intake and NAFLD: NHANES 2017-2020 and Mendelian randomization.

作者信息

Yue Zilong, Jiang Ziming, Qian Long, Li Lele, Qi Xianliang, Hu Kaifeng

机构信息

Department of Gastrointestinal Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.

General Surgery Department, Guoyang Branch of Anhui Provincial Hospital, Bozhou, Anhui, China.

出版信息

Front Nutr. 2024 Oct 30;11:1447524. doi: 10.3389/fnut.2024.1447524. eCollection 2024.

PURPOSE

To determine the association between dietary antioxidant sources and non-alcoholic fatty liver disease (NAFLD).

METHODS

In this observational study, we utilized NHANES 2017-2020 data to identify the factors associated with NAFLD in dietary antioxidant sources via weighted multivariate logistic regression models. Then, Mendelian randomization (MR) was applied to investigate the effect of dietary antioxidant sources on NAFLD at the genetic level.

RESULTS

Of the six dietary sources of antioxidants, only vitamin E (Vit E) was significantly associated with NAFLD (OR = 0.98; 95% CI: 0.97-0.99; = 0.001). Upon adjusting for all covariates, it was determined that the highest quartile of dietary Vit E intake was associated with a decreased NAFLD occurrence compared with the lowest quartile of dietary Vit E intake ( < 0.001). The results of IVW-MR analysis revealed an association between Vit E and NAFLD (OR = 0.028; = 0.039).

CONCLUSION

Our research indicates a negative and linear relationship between daily vitamin E intake and NAFLD.

目的

确定膳食抗氧化剂来源与非酒精性脂肪性肝病（NAFLD）之间的关联。

方法

在这项观察性研究中，我们利用2017 - 2020年美国国家健康与营养检查调查（NHANES）数据，通过加权多变量逻辑回归模型确定膳食抗氧化剂来源中与NAFLD相关的因素。然后，应用孟德尔随机化（MR）方法在基因水平上研究膳食抗氧化剂来源对NAFLD的影响。

结果

在六种膳食抗氧化剂来源中，只有维生素E（Vit E）与NAFLD显著相关（OR = 0.98；95%置信区间：0.97 - 0.99；P = 0.001）。在对所有协变量进行调整后，确定膳食Vit E摄入量最高四分位数与NAFLD发生率降低相关，而膳食Vit E摄入量最低四分位数则不然（P < 0.001）。逆方差加权孟德尔随机化（IVW - MR）分析结果显示Vit E与NAFLD之间存在关联（OR = 0.028；P = 0.039）。