Capó Xavier, Jiménez-Garcia Manuel, Sharopov Farukh, Tsouh Fokou Patrick Valere, Martorell Miquel, Aldahish Afaf Ahmed, Pezzani Raffaele, Sharifi-Rad Javad, Calina Daniela
Translational Research in Aging & Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), Palma, 07120, Spain.
Laboratory of Neurophysiology, Biology Department, University of Balearic Islands (UIB), Palma de Mallorca, Spain.
Future Med Chem. 2024;16(21):2301-2311. doi: 10.1080/17568919.2024.2424150. Epub 2024 Nov 18.
HS-1793 is a novel derivative of resveratrol, a compound known for its numerous beneficial effects, including anticancer activity, anti-inflammatory response, antimicrobial, antiaging, anti-cardiovascular disease activity, neuroprotective activity, etc. Despite its wide and interesting properties, resveratrol suffers from a crucial flaw because it is low bioavailable. For this reason, many other derivatives were explored and among them, HS-1793 has caught the attention of researchers. HS-1793 is a synthetic derivative of resveratrol discovered in 2007 that has been shown to have anti-cancer and anti-inflammatory properties. In addition, the compound showed a positive profile in metabolic processes, with adequate pharmacokinetics and pharmacodynamics. This review highlights current research on HS-1793, evaluating and works and lays the foundation for novel explorative trials in human diseases.
HS - 1793是白藜芦醇的一种新型衍生物,白藜芦醇是一种因具有多种有益作用而闻名的化合物,这些作用包括抗癌活性、抗炎反应、抗菌、抗衰老、抗心血管疾病活性、神经保护活性等。尽管白藜芦醇具有广泛而有趣的特性,但它存在一个关键缺陷,即生物利用度低。因此,人们探索了许多其他衍生物,其中HS - 1793引起了研究人员的关注。HS - 1793是2007年发现的白藜芦醇的合成衍生物,已被证明具有抗癌和抗炎特性。此外,该化合物在代谢过程中表现出良好的特性,具有适当的药代动力学和药效学。本综述重点介绍了目前关于HS - 1793的研究,评估了相关工作,并为人类疾病的新型探索性试验奠定了基础。