Suppr超能文献

揭示HS-1793的潜力:对其抗癌特性及治疗前景的综述

Unveiling the potential of HS-1793: a review of its anticancer properties and therapeutic promise.

作者信息

Capó Xavier, Jiménez-Garcia Manuel, Sharopov Farukh, Tsouh Fokou Patrick Valere, Martorell Miquel, Aldahish Afaf Ahmed, Pezzani Raffaele, Sharifi-Rad Javad, Calina Daniela

机构信息

Translational Research in Aging & Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), Palma, 07120, Spain.

Laboratory of Neurophysiology, Biology Department, University of Balearic Islands (UIB), Palma de Mallorca, Spain.

出版信息

Future Med Chem. 2024;16(21):2301-2311. doi: 10.1080/17568919.2024.2424150. Epub 2024 Nov 18.

Abstract

HS-1793 is a novel derivative of resveratrol, a compound known for its numerous beneficial effects, including anticancer activity, anti-inflammatory response, antimicrobial, antiaging, anti-cardiovascular disease activity, neuroprotective activity, etc. Despite its wide and interesting properties, resveratrol suffers from a crucial flaw because it is low bioavailable. For this reason, many other derivatives were explored and among them, HS-1793 has caught the attention of researchers. HS-1793 is a synthetic derivative of resveratrol discovered in 2007 that has been shown to have anti-cancer and anti-inflammatory properties. In addition, the compound showed a positive profile in metabolic processes, with adequate pharmacokinetics and pharmacodynamics. This review highlights current research on HS-1793, evaluating and works and lays the foundation for novel explorative trials in human diseases.

摘要

HS - 1793是白藜芦醇的一种新型衍生物,白藜芦醇是一种因具有多种有益作用而闻名的化合物,这些作用包括抗癌活性、抗炎反应、抗菌、抗衰老、抗心血管疾病活性、神经保护活性等。尽管白藜芦醇具有广泛而有趣的特性,但它存在一个关键缺陷,即生物利用度低。因此,人们探索了许多其他衍生物,其中HS - 1793引起了研究人员的关注。HS - 1793是2007年发现的白藜芦醇的合成衍生物,已被证明具有抗癌和抗炎特性。此外,该化合物在代谢过程中表现出良好的特性,具有适当的药代动力学和药效学。本综述重点介绍了目前关于HS - 1793的研究,评估了相关工作,并为人类疾病的新型探索性试验奠定了基础。

相似文献

5
Ganoderma lucidum (Reishi mushroom) for cancer treatment.灵芝用于癌症治疗。
Cochrane Database Syst Rev. 2016 Apr 5;4(4):CD007731. doi: 10.1002/14651858.CD007731.pub3.
6
Single-incision sling operations for urinary incontinence in women.女性尿失禁的单切口吊带手术
Cochrane Database Syst Rev. 2017 Jul 26;7(7):CD008709. doi: 10.1002/14651858.CD008709.pub3.
7
Ganoderma lucidum (Reishi mushroom) for cancer treatment.灵芝用于癌症治疗。
Cochrane Database Syst Rev. 2012 Jun 13(6):CD007731. doi: 10.1002/14651858.CD007731.pub2.
9
Selegiline for Alzheimer's disease.司来吉兰用于治疗阿尔茨海默病。
Cochrane Database Syst Rev. 2003(1):CD000442. doi: 10.1002/14651858.CD000442.

本文引用的文献

6
Targeting mutant p53 stabilization for cancer therapy.靶向突变型p53稳定化用于癌症治疗。
Front Pharmacol. 2023 Jul 12;14:1215995. doi: 10.3389/fphar.2023.1215995. eCollection 2023.
7
Targeting Biomolecular Condensation and Protein Aggregation against Cancer.靶向生物分子凝聚和蛋白质聚集治疗癌症。
Chem Rev. 2023 Jul 26;123(14):9094-9138. doi: 10.1021/acs.chemrev.3c00131. Epub 2023 Jun 28.
10
Resveratrol derivatives: Synthesis and their biological activities.白藜芦醇衍生物:合成及其生物活性。
Eur J Med Chem. 2023 Jan 15;246:114962. doi: 10.1016/j.ejmech.2022.114962. Epub 2022 Nov 26.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验