Tang Gan, Lu Jia-Ying, Li Xin-Yi, Yao Rui-Xin, Yang Yu-Jie, Jiao Fang-Yang, Chen Ming-Jia, Liang Xiao-Niu, Ju Zi-Zhao, Ge Jing-Jie, Zhao Yi-Xin, Shen Bo, Wu Ping, Sun Yi-Min, Wu Jian-Jun, Yen Tzu-Chen, Zuo Chuantao, Wang Jian, Zhao Qian-Hua, Zhang Hui-Wei, Liu Feng-Tao
Department of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, and State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Department of Nuclear Medicine and PET Center, National Center for Neurological Disorders, and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Mov Disord. 2025 Jan;40(1):108-120. doi: 10.1002/mds.30055. Epub 2024 Nov 18.
Dementia with Lewy bodies (DLB) commonly exhibits a complex neuropathology, sharing characteristics with Alzheimer's disease (AD), including tau aggregates. However, studies using the F-AV-1451 tau tracer have shown inconsistent findings regarding both the extent and topographical distribution of tau pathology in DLB.
Our aim was to elucidate the topographical patterns of tau deposition in DLB and to investigate the in vivo pathological distinction between DLB and AD in virtue of the F-Florzolotau positron emission tomography (PET) imaging.
This cross-sectional study enrolled patients with DLB (n = 24), AD (n = 43), and cognitively healthy controls (n = 18). Clinical assessments and F-Florzolotau PET imaging were performed. F-Florzolotau binding was quantitatively assessed on PET images using standardized uptake value ratios and voxel-wise analysis.
F-Florzolotau PET imaging revealed widespread tau deposition across various cortical regions in DLB, uncovering heterogeneous topographical patterns. Among patients, 54.17% showed patterns similar to AD, whereas 16.67% exhibited distinct patterns. Compared to AD, DLB exhibited a unique in vivo neuropathological profile, characterized by a lower tau protein burden, heterogeneous topographical distributions, and a specific role of the medial temporal lobe in tau pathology.
F-Florzolotau PET imaging elucidated tau pathology patterns in DLB, providing valuable insights for future in vivo pathological differentiation and potential disease-modifying therapies. © 2024 International Parkinson and Movement Disorder Society.
路易体痴呆（DLB）通常表现出复杂的神经病理学特征，与阿尔茨海默病（AD）有共同特征，包括tau蛋白聚集。然而，使用F-AV-1451 tau示踪剂的研究在DLB中tau病理的范围和拓扑分布方面显示出不一致的结果。
我们的目的是阐明DLB中tau沉积的拓扑模式，并借助F-Florzolotau正电子发射断层扫描（PET）成像研究DLB与AD在体内的病理差异。
这项横断面研究纳入了DLB患者（n = 24）、AD患者（n = 43）和认知健康对照者（n = 18）。进行了临床评估和F-Florzolotau PET成像。使用标准化摄取值比率和体素分析在PET图像上对F-Florzolotau结合进行定量评估。
F-Florzolotau PET成像显示DLB中tau在各个皮质区域广泛沉积，揭示了异质的拓扑模式。在患者中，54.17%表现出与AD相似的模式，而16.67%表现出不同的模式。与AD相比，DLB表现出独特的体内神经病理学特征，其特征为tau蛋白负担较低、拓扑分布异质以及内侧颞叶在tau病理中起特定作用。
F-Florzolotau PET成像阐明了DLB中的tau病理模式，为未来的体内病理分化和潜在的疾病修饰疗法提供了有价值的见解。© 2024国际帕金森和运动障碍协会。
