Sennerstam R, Strömberg J O
Cell Tissue Kinet. 1986 Jan;19(1):71-81.
The 'random transition probability' cell-cycle models have so far failed to convincingly link the transition events with phenomena describable by biochemical methods. The study presented was carried out on the F9 and PCC3 N/1 embryonal carcinoma (EC) cell lines. We now report an extended analysis of the two-random transition probability (TP) model and preliminary results are presented showing that the deterministic L period in that model can be regarded as reflecting the 'cell-growth cycle'. Evidence is presented that suggests that the 'cell-growth cycle' is a supramitotic deterministic phase--i.e. starting in one cell cycle and being completed in the next following G1 period and dissociated from the 'DNA-division cycle'. This phenomenon makes an interesting contribution to the old knowledge of a stepwise G1 prolongation during early embryogenesis in yielding a mechanism by which the cell can alter the ratio of nucleus to cytoplasm prior to the onset of gene expression.
到目前为止，“随机转变概率”细胞周期模型未能令人信服地将转变事件与可用生化方法描述的现象联系起来。本研究是在F9和PCC3 N/1胚胎癌细胞系上进行的。我们现在报告对双随机转变概率（TP）模型的扩展分析，并展示初步结果，表明该模型中的确定性L期可被视为反映“细胞生长周期”。有证据表明，“细胞生长周期”是一个超有丝分裂确定性阶段——即始于一个细胞周期，并在下一个紧接着的G1期完成，且与“DNA分裂周期”相分离。这一现象为早期胚胎发育过程中G1期逐步延长的旧有知识做出了有趣的贡献，为细胞在基因表达开始之前改变核质比提供了一种机制。
