Coutinho Danila Felix, Freitas Túlio Resende, Silva Batista Ana Carolina, Quezado de Magalhães Mariana Torquato, Sabino Adriano de Paula
Department of Clinical and Toxicological Analyses, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.
Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.
J Proteome Res. 2024 Dec 6;23(12):5263-5273. doi: 10.1021/acs.jproteome.4c00807. Epub 2024 Nov 18.
The study of circulating peptides in the blood offers significant opportunities for diagnosing, stratifying, and managing various diseases. With recent technological advances and the ongoing need to understand complex diseases such as acute leukemias (AL), peptidomic analysis of peripheral blood, especially serum and plasma, has become increasingly important for studying human biology and pathophysiology. Here, we provide insights and perspectives on technological developments and potential clinical applications using widely used peptidomic analysis methods. We discuss examples where peptidomics using serum or plasma has contributed to the understanding of AL. Specifically, we highlight the scarcity of peptidomic studies applied to AL and emphasize the importance of exploring this area, as the few published studies present promising results that can significantly contribute to precision medicine.
对血液中循环肽的研究为各种疾病的诊断、分层和管理提供了重要机遇。随着近期技术的进步以及对诸如急性白血病（AL）等复杂疾病持续深入了解的需求，对外周血，尤其是血清和血浆进行肽组学分析，对于研究人类生物学和病理生理学变得越来越重要。在此，我们运用广泛使用的肽组学分析方法，就技术发展和潜在临床应用提供见解和观点。我们讨论了利用血清或血浆进行肽组学研究有助于理解急性白血病的实例。具体而言，我们强调应用于急性白血病的肽组学研究稀缺，并强调探索该领域的重要性，因为少数已发表的研究呈现出有前景的结果，可为精准医学做出重大贡献。
