肿瘤坏死因子-α/白细胞介素-1β/白细胞介素-1α/白细胞介素-12炎性细胞因子轴，与Toll样受体1/ Toll样受体3/ Toll样受体5/髓样分化因子88免疫信号通路过度激活共同作用，导致老年患者同时出现颈动脉和冠状动脉粥样硬化及闭塞。
TNF-α/IL-1β/IL-1α/IL-12 inflammatory cytokine axes coupled with TLR1/TLR3/TLR5/MYD88 immune signaling pathway over-activation contribute to simultaneous carotid and coronary artery and occlusion in elderly patients.
作者信息
Zhou Wenhang, Li Xia, Zhou Hualan, Hu Youdong, Chen Ying, Guo Dianxuan
机构信息
Xiamen Road Branch Hospital, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223005, China.
Department of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, China.
出版信息
Cytokine. 2025 Jan;185:156808. doi: 10.1016/j.cyto.2024.156808. Epub 2024 Nov 17.
BACKGROUND
It remains difficult to evaluate the risk factors for concomitant carotid artery as well as coronary artery diseases in elderly patients. The aim of this research was to determine the TNF-α/IL-1β/IL-1α/IL-12 axes-TLR1/TLR3/TLR5/MYD88 immune signaling pathway interactions in coexistent carotid artery occlusion and coronary artery occlusion in elderly patients.
METHODS
Elderly patients, who underwent carotid ultrasonography and coronary computed tomography angiography, were consecutively included in this research. The analyzed groups consisted of those with coexistent carotid artery occlusion and coronary artery occlusion as well as healthy individuals were enrolled as control group. The circulating levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-1α (IL-1α), interleukin-12 (IL-12), toll-like receptor 1 (TLR1), toll-like receptor 3 (TLR3), toll-like receptor 5 (TLR5) and myeloid differentiation factor 88 (MYD88) were measured.
RESULTS
The biomarkers (TNF-α, IL-1β, IL-1α, IL-12, TLR1, TLR3, TLR5 and MYD88) were significantly increased in carotid artery occlusion + left circumflex coronary artery occlusion group when compared with control group and carotid artery occlusion + right coronary artery occlusion group, respectively (P < 0.001), and were further elevated in carotid artery occlusion + left anterior descending coronary artery occlusion group when compared to carotid artery occlusion + right coronary artery occlusion group and carotid artery occlusion + left circumflex coronary artery occlusion group, respectively (P < 0.001).
CONCLUSION
This research demonstrated that the TNF-α/IL-1β/IL-1α/IL-12 axes and TLR1/TLR3/TLR5/MYD88 immune signaling pathway implicated in the pathogenesis of carotid artery occlusion with coronary artery occlusion in elderly patients.
背景
评估老年患者合并颈动脉疾病和冠状动脉疾病的危险因素仍然困难。本研究的目的是确定老年患者并存颈动脉闭塞和冠状动脉闭塞时肿瘤坏死因子-α/白细胞介素-1β/白细胞介素-1α/白细胞介素-12轴与Toll样受体1/Toll样受体3/Toll样受体5/髓样分化因子88免疫信号通路的相互作用。
方法
连续纳入接受颈动脉超声检查和冠状动脉计算机断层扫描血管造影的老年患者。分析组包括并存颈动脉闭塞和冠状动脉闭塞的患者，健康个体作为对照组。检测肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-1α（IL-1α）、白细胞介素-12（IL-12）、Toll样受体1（TLR-1）、Toll样受体3（TLR-3）、Toll样受体5（TLR-5）和髓样分化因子88（MYD88）的循环水平。
结果
与对照组和颈动脉闭塞+右冠状动脉闭塞组相比，颈动脉闭塞+左旋支冠状动脉闭塞组的生物标志物（TNF-α、IL-1β、IL-1α、IL-12、TLR-1、TLR-3、TLR-5和MYD88）显著升高（P<0.001），与颈动脉闭塞+右冠状动脉闭塞组和颈动脉闭塞+左旋支冠状动脉闭塞组相比，颈动脉闭塞+左前降支冠状动脉闭塞组的生物标志物进一步升高（P<0.001）。
结论
本研究表明，TNF-α/IL-1β/IL-1α/IL-12轴和TLR-1/TLR-3/TLR-5/MYD88免疫信号通路与老年患者颈动脉闭塞合并冠状动脉闭塞的发病机制有关。
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