Department of Orthopedics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Department of Orthopedics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
BMJ Open. 2024 Nov 18;14(11):e084306. doi: 10.1136/bmjopen-2024-084306.
Tandem Spinal Stenosis (TSS) is a disease characterised by the narrowing of the spinal canal in two or more non-adjacent areas of the spine, often affecting both the cervical and lumbar vertebrae. Doctors and patients increasingly favour non-surgical treatments that have the function of relieving symptoms and improving outcomes. This systematic review aims to evaluate the effectiveness and safety of non-surgical therapies for TSS and comprehensively summarise existing evidence.
We will conduct comprehensive searches, both manual and electronic, of literature published up to 30 September 2024; database searches will commence after the publication of this agreement, with an estimated commencement date of 1 December 2024, and the end date is 31 May 2025, without language restrictions. Key databases such as MEDLINE, PubMed, EMBASE, Web of Science, Cochrane Library, WHO International Clinical Trial Registration Platform, China National Knowledge Infrastructure, China Biomedical Literature Database, China Scientific Journal Database and Wan-Fang Database will be explored. In addition, we will include resources such as library journals and conference abstracts. Following the identification and screening of all randomised controlled trials focusing on non-surgical treatments for TSS, two investigators will perform a meta-analysis of the included studies. The findings will be summarised as the risk ratio for binary data and the standardised or weighted mean difference for continuous data.
Ethical approval is not required, as the review does not involve individual patient data. The review's findings will provide clinicians with evidence on using non-surgical treatments for TSS, disseminated through peer-reviewed publications or conferences.
CRD42024496634.
串联性椎管狭窄症（TSS）是一种以脊柱两个或多个非相邻区域椎管狭窄为特征的疾病，通常影响颈椎和腰椎。医生和患者越来越倾向于选择具有缓解症状和改善预后功能的非手术治疗方法。本系统评价旨在评估 TSS 的非手术治疗方法的有效性和安全性，并全面总结现有证据。
我们将对截至 2024 年 9 月 30 日发表的文献进行全面的手动和电子检索；数据库检索将在本协议发布后开始，预计开始日期为 2024 年 12 月 1 日，结束日期为 2025 年 5 月 31 日，不限制语言。将探索 MEDLINE、PubMed、EMBASE、Web of Science、Cochrane 图书馆、世界卫生组织国际临床试验注册平台、中国国家知识基础设施、中国生物医学文献数据库、中国科学期刊数据库和万方数据库等主要数据库。此外，我们还将包括图书馆期刊和会议摘要等资源。在对所有关注 TSS 非手术治疗的随机对照试验进行识别和筛选后，两名调查员将对纳入的研究进行荟萃分析。研究结果将以二项数据的风险比和连续数据的标准化或加权均数差进行总结。
不需要伦理批准，因为审查不涉及个体患者数据。审查结果将为临床医生提供关于使用 TSS 非手术治疗的证据，通过同行评审出版物或会议进行传播。
PROSPERO 注册号：CRD42024496634。
