Ontan Mehmet Selman, Cam Mahser Alev, Dost Fatma Sena, Isik Ahmet Turan
Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Department of Geriatric Medicine, Darica Farabi Training and Research Hospital, Kocaeli, Turkey.
Osteoporos Int. 2025 Jan;36(1):123-128. doi: 10.1007/s00198-024-07317-9. Epub 2024 Nov 18.
Both osteoporosis and idiopathic normal pressure hydrocephalus may increase the risk of falls and fractures. This study showed that osteoporosis is more common in older patients with iNPH. It is important to raise awareness of osteoporosis in older patients with iNPH to prevent adverse health consequences.
Idiopathic normal pressure hydrocephalus (iNPH), a potentially reversible condition with timely intervention, may cause cognitive impairment, balance and gait disturbance, and urinary incontinence in advanced age. Osteoporosis is a progressive metabolic bone disease that increases bone fragility in older adults. Both conditions may lead to falls and fractures. Therefore, this study aims to investigate osteoporosis in older adults with iNPH.
A total of 64 patients diagnosed with iNPH and 458 participants in the control group were included in the study. Demographic and clinical characteristics, including age, sex, comorbidities, laboratory findings, and comprehensive geriatric assessment parameters, were recorded. Osteoporosis was defined according to the WHO classification. The relationship between osteoporosis and iNPH was assessed with regression analysis.
The mean age was higher in the iNPH group than in the control group (79.91 ± 6.36 vs 75.86 ± 6.51 years, p < 0.001). The frequency of female patients was higher in the control group than in the iNPH group (81% vs 70.3%, p = 0.046). The osteoporosis frequency was higher in the iNPH group than in the controls (51.6% vs 32.1%, p = 0.002). Adjusted for age and gender, iNPH was associated with osteoporosis (odds ratio (OR), 1.750; confidence interval (CI) 95%, 1.002-3.054; p = 0.049).
This study showed that osteoporosis is more common in older patients with iNPH. Therefore, screening and treatment of osteoporosis in these individuals is crucial to avoid adverse health outcomes such as fractures.
骨质疏松症和特发性正常压力脑积水均可能增加跌倒和骨折的风险。本研究表明，骨质疏松症在老年特发性正常压力脑积水患者中更为常见。提高对老年特发性正常压力脑积水患者骨质疏松症的认识对于预防不良健康后果很重要。
特发性正常压力脑积水（iNPH）是一种经及时干预可能可逆的病症，在老年时可能导致认知障碍、平衡和步态障碍以及尿失禁。骨质疏松症是一种进行性代谢性骨病，会增加老年人的骨脆性。这两种情况都可能导致跌倒和骨折。因此，本研究旨在调查老年特发性正常压力脑积水患者的骨质疏松症情况。
本研究共纳入64例诊断为特发性正常压力脑积水的患者和458例对照组参与者。记录人口统计学和临床特征，包括年龄、性别、合并症、实验室检查结果和综合老年评估参数。骨质疏松症根据世界卫生组织分类进行定义。采用回归分析评估骨质疏松症与特发性正常压力脑积水之间的关系。
特发性正常压力脑积水组的平均年龄高于对照组（79.91±6.36岁对75.86±6.51岁，p<0.001）。对照组女性患者的频率高于特发性正常压力脑积水组（81%对70.3%，p=0.046）。特发性正常压力脑积水组的骨质疏松症频率高于对照组（51.6%对32.1%，p=0.002）。在调整年龄和性别后，特发性正常压力脑积水与骨质疏松症相关（优势比（OR）为1.750；95%置信区间（CI）为1.002 - 3.054；p=0.049）。
本研究表明，骨质疏松症在老年特发性正常压力脑积水患者中更为常见。因此，对这些个体进行骨质疏松症的筛查和治疗对于避免骨折等不良健康结局至关重要。
