炎症为基础的营养工具（格拉斯哥预后评分）与血液肿瘤患者住院时间的相关性。

The association between an inflammation-based nutritional tool (Glasgow Prognostic Score) and length of hospital stay in patients with haematological cancer.

机构信息

Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Department of Haematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

出版信息

Support Care Cancer. 2024 Nov 19;32(12):804. doi: 10.1007/s00520-024-09021-0.

DOI:10.1007/s00520-024-09021-0

PMID:39557734

Abstract

BACKGROUND

This is a retrospective study to identify if Glasgow Prognostic Score (GPS) is associated with length of hospital stay (LOS) in haematological cancer.

METHODS

The participants were adult inpatients at a single centre in between 2018 and 2022. Serum levels of CRP and albumin were measured at admission. GPS was calculated as follows: point "0" as CRP < 10 mg/L and albumin ≥ 35 g/L; point "2" as CRP ≥ 10 mg/L and albumin < 35 g/L; point "1" as either CRP ≥ 10 mg/L or albumin < 35 g/L. Patients with point "0" were classified as low risk whilst point "2" as high risk. LOS was defined as the interval between the admission and discharge date.

RESULTS

As a result, the average age was 59.6 ± 12.6 years and the average LOS was 6.0 days (IQR = 2 days, 11 days). Of 1621 patients, 8.8% of them were high risk. GPS was associated with LOS (β = 2.7 days; 95% CI = 0.8 days, 4.6 days; p trend < 0.001) after full adjustment. Each point of GPS was associated with 1.9 days (95% CI = 1.4 days, 2.4 days) longer in LOS with full adjustment. The association was more prominent in younger patients (< 65 years), patients with leukaemia and myelodysplastic syndrome, and those with normal body weight status (18.5-24 kg/m), compared with their counterparts.

CONCLUSION

GPS was associated with LOS in Chinese patients with haematological cancer, indicating GPS could be a useful tool to predict outcome.

摘要

背景

本研究旨在确定格拉斯哥预后评分（GPS）是否与血液系统恶性肿瘤患者的住院时间（LOS）相关。

方法

研究对象为 2018 年至 2022 年间在某单中心住院的成年患者。入院时检测血清 CRP 和白蛋白水平。GPS 计算方法如下：CRP<10mg/L 且白蛋白≥35g/L 为 0 分；CRP≥10mg/L 且白蛋白<35g/L 为 2 分；CRP≥10mg/L 或白蛋白<35g/L 为 1 分。CRP<10mg/L 且白蛋白≥35g/L 患者归为低危组，CRP≥10mg/L 且白蛋白<35g/L 患者归为高危组。LOS 定义为入院日期至出院日期之间的时间间隔。

结果

本研究共纳入 1621 例患者，平均年龄为 59.6±12.6 岁，平均 LOS 为 6.0 天（IQR=2 天，11 天）。其中高危组患者占 8.8%。多因素调整后，GPS 与 LOS 相关（β=2.7 天；95%CI=0.8 天，4.6 天；p 趋势<0.001）。GPS 每增加 1 分，LOS 延长 1.9 天（95%CI=1.4 天，2.4 天）。在年龄<65 岁、白血病和骨髓增生异常综合征患者、体重正常（18.5-24kg/m2）患者中，GPS 与 LOS 的相关性更为显著。