Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Haematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Support Care Cancer. 2024 Nov 19;32(12):804. doi: 10.1007/s00520-024-09021-0.
This is a retrospective study to identify if Glasgow Prognostic Score (GPS) is associated with length of hospital stay (LOS) in haematological cancer.
The participants were adult inpatients at a single centre in between 2018 and 2022. Serum levels of CRP and albumin were measured at admission. GPS was calculated as follows: point "0" as CRP < 10 mg/L and albumin ≥ 35 g/L; point "2" as CRP ≥ 10 mg/L and albumin < 35 g/L; point "1" as either CRP ≥ 10 mg/L or albumin < 35 g/L. Patients with point "0" were classified as low risk whilst point "2" as high risk. LOS was defined as the interval between the admission and discharge date.
As a result, the average age was 59.6 ± 12.6 years and the average LOS was 6.0 days (IQR = 2 days, 11 days). Of 1621 patients, 8.8% of them were high risk. GPS was associated with LOS (β = 2.7 days; 95% CI = 0.8 days, 4.6 days; p trend < 0.001) after full adjustment. Each point of GPS was associated with 1.9 days (95% CI = 1.4 days, 2.4 days) longer in LOS with full adjustment. The association was more prominent in younger patients (< 65 years), patients with leukaemia and myelodysplastic syndrome, and those with normal body weight status (18.5-24 kg/m), compared with their counterparts.
GPS was associated with LOS in Chinese patients with haematological cancer, indicating GPS could be a useful tool to predict outcome.
本研究旨在确定格拉斯哥预后评分（GPS）是否与血液系统恶性肿瘤患者的住院时间（LOS）相关。
研究对象为 2018 年至 2022 年间在某单中心住院的成年患者。入院时检测血清 CRP 和白蛋白水平。GPS 计算方法如下：CRP<10mg/L 且白蛋白≥35g/L 为 0 分；CRP≥10mg/L 且白蛋白<35g/L 为 2 分；CRP≥10mg/L 或白蛋白<35g/L 为 1 分。CRP<10mg/L 且白蛋白≥35g/L 患者归为低危组，CRP≥10mg/L 且白蛋白<35g/L 患者归为高危组。LOS 定义为入院日期至出院日期之间的时间间隔。
本研究共纳入 1621 例患者，平均年龄为 59.6±12.6 岁，平均 LOS 为 6.0 天（IQR=2 天，11 天）。其中高危组患者占 8.8%。多因素调整后，GPS 与 LOS 相关（β=2.7 天；95%CI=0.8 天，4.6 天；p 趋势<0.001）。GPS 每增加 1 分，LOS 延长 1.9 天（95%CI=1.4 天，2.4 天）。在年龄<65 岁、白血病和骨髓增生异常综合征患者、体重正常（18.5-24kg/m2）患者中，GPS 与 LOS 的相关性更为显著。
在中国血液系统恶性肿瘤患者中，GPS 与 LOS 相关，提示 GPS 可能是预测预后的有用工具。
