Department of Mathematics, Ghazi University, D G Khan, 32200, Pakistan.
Mathematics Research Center, Near East University, Near East Boulevard, Nicosia North Cyprus, 99138, Turkey.
Sci Rep. 2024 Nov 18;14(1):28463. doi: 10.1038/s41598-024-79597-4.
Reformulating the physical processes associated with the evolution of different ailments in accordance with globally shared objectives is crucial for deeper comprehension. This study aims to investigate the mechanism by which the HB virus induces harmful inflammation of the liver, with a focus on early detection and therapy using corticosteroids or chemotherapy. Based on the developed hypothesis, a new mathematical model has been created for this purpose. The recently developed system for HBV is , which is examined both quantitatively and qualitatively to determine its actual effect on stability. Reliable conclusions are ensured by examining the system's boundedness, positivity, existence, uniqueness, and conducting local and global stability analysis-all crucial components of epidemic models. Global stability is tested using Lyapunov first derivative functions to assess the overall impact of asymptomatic persons and chemotherapy treatment. Additionally, the Lipschitz condition is used to confirm the unique solutions for the newly built HBV model using methods from fixed point theory, thus meeting the requirements for uniqueness and existence. Since the population must maintain this property, positivity is confirmed using global derivatives and Lipschitz criteria to calculate the rate of change in each sub-compartment. Applying the Mittag-Leffler kernel with a fractal-fractional operator to continuously monitor the HBV virus for liver cirrhosis infection yields dependable results. Furthermore, the current situation regarding the HBV outbreak pertaining to liver cirrhosis infection, along with the control measures implemented following early diagnosis through asymptomatic measures and chemotherapy treatment under constant observation, are established to prevent chronic stage infections. Simulations have been used to study the true behavior and impact of HBV in asymptomatic persons receiving chemotherapy for liver cirrhosis infection in the community. This research is essential for understanding the spread of viruses and developing control strategies based on our validated findings to mitigate the risk factors associated with liver cirrhosis.
根据全球共享目标,重新制定与不同疾病演变相关的物理过程对于深入理解至关重要。本研究旨在探讨乙型肝炎病毒(HBV)诱导肝脏有害炎症的机制,重点是使用皮质类固醇或化疗进行早期检测和治疗。基于已提出的假说,为此目的创建了一个新的数学模型。最近开发的 HBV 系统是 ,对其进行了定量和定性检查,以确定其对稳定性的实际影响。通过检查系统的有界性、正定性、存在性、唯一性,并进行局部和全局稳定性分析,可以确保得出可靠的结论,这些都是传染病模型的关键组成部分。使用李雅普诺夫第一导数函数进行全局稳定性测试,以评估无症状者和化疗治疗的总体影响。此外,使用 Lipschitz 条件通过固定点理论的方法来确认新建立的 HBV 模型的唯一解,从而满足唯一性和存在性的要求。由于种群必须保持这种特性,因此使用全局导数和 Lipschitz 准则来确认正定性,以计算每个子室的变化率。使用分数阶算子的 Mittag-Leffler 核来连续监测 HBV 病毒是否会导致肝硬化感染,从而获得可靠的结果。此外,还建立了针对肝硬化感染的 HBV 爆发的现状,以及通过无症状措施和化疗治疗进行早期诊断并持续观察后的控制措施,以预防慢性阶段的感染。模拟已用于研究社区中接受化疗治疗肝硬化感染的无症状者中 HBV 的真实行为和影响。这项研究对于了解病毒的传播和制定基于我们验证结果的控制策略以减轻与肝硬化相关的风险因素至关重要。