Department of Pharmacy, Dazhou Central Hospital, Dazhou, 635000, People's Republic of China.
Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People's Republic of China.
Sci Rep. 2024 Nov 18;14(1):28494. doi: 10.1038/s41598-024-79260-y.
Metabolic syndrome (MetS) is closely linked to cancer development, with emerging evidence suggesting its association with pulmonary carcinoma. However, causal relationships remain unclear due to observational study limitations. Employing Mendelian randomization, we investigated the causal link between MetS and lung cancer (LC) susceptibility. The data utilized in this study were obtained from the publicly available genetic variation summary database. The causal relationship was assessed using the inverse variance weighting method (IVW), weighted median method, and MR-Egger regression. A sensitivity analysis was carried out to confirm the robustness of the findings. Furthermore, risk factor analyses were conducted to explore potential mediators. Utilizing various analyses, MetS demonstrated a significant positive association with LC (OR, 1.22; 95% CI, 1.09-1.37, p = 7.57 × 10), lung squamous cell carcinoma (LUSC) (OR, 1.47; 95%, 1.23-1.75, p = 2.22 × 10), and small cell lung cancer (SCLC) (OR, 1.76; 95% CI, 1.37-2.26, p = 8.20 × 10) but not lung adenocarcinoma (LUAD) (OR, 1.08; 95% CI, 0.94-1.24, p = 0.28). Risk factor analyses indicated that smoking, alcohol, body mass index, education, and type 2 diabetes might mediate the association. This study genetically validates and reinforces the evidence of MetS increasing the incidence of LC, including both LUSC) and SCLC, especially among individuals with abdominal obesity. It provides valuable insights for the development of lung cancer prevention strategies and directions for future research.
代谢综合征（MetS）与癌症的发生密切相关，越来越多的证据表明其与肺癌有关。然而，由于观察性研究的局限性，因果关系尚不清楚。本研究采用孟德尔随机化方法，探讨 MetS 与肺癌（LC）易感性之间的因果关系。本研究使用的数据分析来源于公共可用的遗传变异综合数据库。采用逆方差加权法（IVW）、加权中位数法和 MR-Egger 回归法评估因果关系。采用敏感性分析来验证结果的稳健性。此外，还进行了风险因素分析以探讨潜在的中介因素。通过多种分析方法，MetS 与 LC（OR，1.22；95%CI，1.09-1.37，p=7.57×10）、肺鳞状细胞癌（LUSC）（OR，1.47；95%CI，1.23-1.75，p=2.22×10）和小细胞肺癌（SCLC）（OR，1.76；95%CI，1.37-2.26，p=8.20×10）呈显著正相关，但与肺腺癌（LUAD）（OR，1.08；95%CI，0.94-1.24，p=0.28）无关。风险因素分析表明，吸烟、饮酒、体重指数、教育程度和 2 型糖尿病可能是这种关联的中介因素。本研究从遗传学上证实并加强了 MetS 增加 LC 发病率的证据，包括 LUSC 和 SCLC，尤其是在腹型肥胖者中。这为制定肺癌预防策略提供了有价值的见解，并为未来的研究指明了方向。
