了解乳腺癌的遗传结构：蛋白质组全关联研究如何发挥作用？
Understanding genetic architecture of breast cancer: how can proteome-wide association studies contribute?
作者信息
Sun Yijia, Huo Dezheng
机构信息
Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.
出版信息
Br J Cancer. 2024 Dec;131(12):1869-1870. doi: 10.1038/s41416-024-02905-2. Epub 2024 Nov 18.
Abstract
Proteome-wide association studies (PWAS) address gaps in post-transcriptional modifications that previous genome- and transcriptome-wide association studies could not capture. Zhao and colleagues conducted the first breast tissue-based PWAS and identified proteins associated with breast cancer risk, providing insights into the role of protein expression in breast cancer development.
摘要
全蛋白质组关联研究（PWAS）填补了先前全基因组和全转录组关联研究未能捕捉到的转录后修饰方面的空白。赵及其同事开展了首个基于乳腺组织的PWAS，并鉴定出与乳腺癌风险相关的蛋白质，为蛋白质表达在乳腺癌发展中的作用提供了见解。
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本文引用的文献
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Multi-tissue transcriptome-wide association studies identified 235 genes for intrinsic subtypes of breast cancer.多组织转录组全基因组关联研究鉴定了 235 个乳腺癌内在亚型的基因。
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SEPepQuant enhances the detection of possible isoform regulations in shotgun proteomics.SEPepQuant 增强了 shotgun 蛋白质组学中可能的同工型调控检测。
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Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility.乳腺癌、前列腺癌、卵巢癌和子宫内膜癌的预测蛋白质组关联研究提示血浆蛋白质调节与癌症易感性有关。
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