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一种靶向线粒体的双核 Ir-Ru 配合物，作为协同光激活化疗和光动力疗法药物，用于治疗顺铂耐药肿瘤细胞。

A mitochondria-targeting dinuclear Ir-Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells.

机构信息

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.

出版信息

Chem Commun (Camb). 2019 Oct 25;55(83):12547-12550. doi: 10.1039/c9cc05998a. Epub 2019 Oct 2.

DOI:10.1039/c9cc05998a
PMID:31576841
Abstract

A mitochondria-targeting hetero-binuclear Ir(iii)-Ru(ii) complex was developed as a photoactivated chemotherapy (PACT) and photodynamic therapy (PDT) bifunctional agent to achieve a synergistic effective therapeutic outcome for the therapy of cisplatin-resistant tumour cells.

摘要

一种靶向线粒体的异双核 Ir(iii)-Ru(ii) 配合物被开发为光激活化疗 (PACT) 和光动力治疗 (PDT) 的双功能试剂，以实现协同有效的治疗效果，用于治疗顺铂耐药的肿瘤细胞。

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