Lee Sang Hwan, Ryu Soo Rack, Yoo Kyung Hun, Lee Juncheol, Cho Yongil, Lim Tae Ho, Kang Hyunggoo, Oh Jaehoon, Ko Byuk Sung
Department of Emergency Medicine, Hanyang University College of Medicine, Seoul, Korea.
Biostatistical Consulting and Research Laboratory, Medical Research Collaborating Center, Hanyang University, Seoul, Korea.
Acute Crit Care. 2024 Nov;39(4):526-534. doi: 10.4266/acc.2024.00199. Epub 2024 Nov 18.
Carbon monoxide (CO) poisoning can lead to significant morbidity and mortality. However, relatively few studies have investigated its long-term mortality impact. This nationwide population-based cohort study examined the association between CO poisoning and long-term mortality.
This retrospective study utilized data from the National Health Insurance Service database in South Korea. We compared the patients with CO poisoning to those without CO poisoning. Inverse probability treatment weights were applied to both groups to control for potential confounding factors. Subsequently, mortality was assessed using the incidence rate and Cox proportional hazard ratios.
This study included 23,387 patients with CO poisoning and 359,851 without it. Over a median follow-up period of 7.6 years after CO poisoning diagnosis, the mortality risk was 2.6 times higher in patients with CO poisoning compared to that in the control group. In a long-term follow-up of patients surviving beyond 30 days, mortality remained 2.18 times higher. Additionally, a higher mortality risk was observed in the relatively younger age group (18-39 years) and the group with fewer underlying diseases, as indicated by a Charlson Comorbidity Index score of 0.
CO poisoning is associated with an elevated long-term mortality rate particularly in a relatively young and healthy population.
一氧化碳（CO）中毒可导致严重的发病和死亡。然而，相对较少的研究调查了其对长期死亡率的影响。这项基于全国人群的队列研究探讨了CO中毒与长期死亡率之间的关联。
这项回顾性研究利用了韩国国民健康保险服务数据库中的数据。我们将CO中毒患者与未患CO中毒的患者进行了比较。对两组均应用逆概率处理权重以控制潜在的混杂因素。随后，使用发病率和Cox比例风险比评估死亡率。
本研究纳入了23387例CO中毒患者和359851例未中毒患者。在CO中毒诊断后的中位随访期7.6年里，CO中毒患者的死亡风险是对照组的2.6倍。在对存活超过30天的患者进行长期随访时，死亡率仍高出2.18倍。此外，在相对年轻的年龄组（18 - 39岁）和基础疾病较少的组（Charlson合并症指数评分为0）中观察到较高的死亡风险。
CO中毒与长期死亡率升高有关，尤其是在相对年轻和健康的人群中。
