Ostach Pia Ks, Dülsner André, Keil Anne, Nagel-Riedasch Stefan
Charité-Universitätsmedizin Berlin, Forschungseinrichtungen für Experimentelle Medizin, Germany.
Charité-Universitätsmedizin Berlin, Arbeitsmedizinisches Zentrum, Germany.
Lab Anim. 2025 Feb;59(1):93-103. doi: 10.1177/00236772241271028. Epub 2024 Nov 19.
When biomedical research investigates the human surgical situation in the need of a chronic course, it is more often possible to do so using large animal models. The use of farm animals always poses special challenges for the institution conducting the research in terms of infection prevention and occupational safety. Especially for the zoonotic disease coxiellosis it is important to be aware of the constant risk of pathogen introduction by small ruminants and to take appropriate precautions. In this way, personal injury should be avoided or at least be kept to a minimum in the event of infection since then sustainable zoonosis control can be immediately initiated. Using the example of a Q fever outbreak at a research facility, we want to share with this extended case report the importance of central emergency structures, provisions and the inclusion of relevant experts and disciplines in a crisis team. Its primary purpose is to support the affected facility and coordinate the implementation of necessary cleaning, disinfection and decontamination measures in close contact with the responsible local authorities. The aim is to inactivate the pathogen in a systematic and controlled manner in few steps of action only and to keep the interruption of the facility's operations as short as possible.
当生物医学研究需要对慢性病程的人体手术情况进行调查时，使用大型动物模型往往更可行。在预防感染和职业安全方面，使用农场动物对开展研究的机构始终构成特殊挑战。特别是对于人畜共患病柯氏杆菌病，必须意识到小型反刍动物带来的病原体引入持续风险，并采取适当的预防措施。这样，在发生感染时应避免人身伤害，或者至少将其降至最低程度，因为届时可持续的人畜共患病控制可立即启动。以某研究机构的一次Q热疫情为例，我们希望通过这份扩展病例报告，分享中央应急结构、规定以及让相关专家和学科加入危机应对小组的重要性。其主要目的是支持受影响的机构，并与负责的地方当局密切合作，协调实施必要的清洁、消毒和去污措施。目标是仅通过几个行动步骤，以系统且可控的方式使病原体失活，并尽可能缩短机构运营的中断时间。
