Maqsood Reshaib, Gul Samreen, Malik Junaid, Ali Ihsan
Government Medical College Srinagar, House No. 1, Block C, Budshah Nagar Natipora, Srinagar, Jammu and Kashmir India.
Indian J Otolaryngol Head Neck Surg. 2024 Dec;76(6):5542-5548. doi: 10.1007/s12070-024-05026-7. Epub 2024 Oct 4.
Nasal polyps are epithelial and stromal non-neoplastic proliferations of nasal cavity and paranasal sinuses. Nasal polyps are a consequence of damage in the epithelium of the nasal mucosa. Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they are considered potentially responsible for the etiopathogenesis and prognosis of the disease. This cross-sectional observational study was conducted in the department of ENT, H&NS, Government Medical College, Srinagar. A total of 62 patients were included in the study. The recorded data was compiled and entered in a spreadsheet (Microsoft Excel) and then exported to data editor of SPSS Version 20.0 (SPSS Inc., Chicago, Illinois, USA). A total of 62 patients participated in the study. Majority of subjects were in the age group of 60-69 and the least number in 20-29. 47 patients had a mean lund kennedyscore of 13.34 ± 1.178 with peripheral eosinophil count of ≥ 500 and 15 patients had a score of 7.00 ± 0.632 with peripheral eosinophil count of < 500. 50 patients had a mean lund kennedy score of 13.04 ± 1.359 with tissue eosinophil count of ≥ 10/HPF and 12 patients had a score of 7.16 ± 0.669 with atissue eosinophil count of < 10/HPF. The conducted study indicates that the levels of tissue and peripheral osinophils are positively related to severity of nasal polyps as indicated by Lund Kennedy scores. Also, our study concluded that the disease has male preponderance.
鼻息肉是鼻腔和鼻窦的上皮及间质非肿瘤性增生。鼻息肉是鼻黏膜上皮损伤的结果。由于嗜酸性粒细胞是大部分鼻息肉组织中的主要炎症细胞，它们被认为可能对该疾病的病因发病机制和预后负责。这项横断面观察性研究在斯利那加政府医学院耳鼻喉头颈外科进行。共有62名患者纳入该研究。记录的数据被整理并录入电子表格（微软Excel），然后导出到SPSS 20.0版本的数据编辑器（SPSS公司，美国伊利诺伊州芝加哥）。共有62名患者参与了该研究。大多数受试者年龄在60 - 69岁之间，20 - 29岁的人数最少。47名患者的平均伦德·肯尼迪评分为13.34±1.178，外周嗜酸性粒细胞计数≥500，15名患者的评分为7.00±0.632，外周嗜酸性粒细胞计数<500。50名患者的平均伦德·肯尼迪评分为13.04±1.359，组织嗜酸性粒细胞计数≥10/HPF，12名患者的评分为7.16±0.669，组织嗜酸性粒细胞计数<10/HPF。所进行的研究表明，如伦德·肯尼迪评分所示，组织和外周嗜酸性粒细胞水平与鼻息肉的严重程度呈正相关。此外，我们的研究得出结论，该疾病男性居多。
