Aslan Figen, Altun Eren, Paksoy Serpil, Turan Gulay
Balıkesir Universty School of medicine, Pathology Department, Balıkesir, Turkey.
Multidiscip Respir Med. 2017 Aug 21;12:21. doi: 10.1186/s40248-017-0102-7. eCollection 2017.
Although nasal polyps are one of the most frequent diseases, their etiopathogenesis remains unclear.Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they are considered potentially responsible for the etiopathogenesis and prognosis of the disease. Aim of this study was to investigate the relation between mucosal and peripheral eosinophilia and their relation with disease severity in nasal polyps.
The study included 53 patients with nasal polyps who underwent endoscopic sinus surgery. Preoperative Lund-MacKay computed tomography (CT) scores and the Lund-Kennedy endoscopic scores of the patients were recorded. Nasal polyp tissues were stained with hematoxylin and eosin, eosinophil counts were performed using high-power field (HPF, 400×) under the light microscope, and the patients were grouped as those with high mucosal eosinophil count and those with low mucosal eosinophil count.
The mean Lund-MacKay CT score and the mean Lund-Kennedy endoscopic score were higher in the patients with high mucosal eosinophil count than in those with low mucosal eosinophil count. Likewise, the mean Lund-MacKay CT score and the mean Lund-Kennedy endoscopic scores were significantly higher in the patients with high peripheral eosinophil count than in those with low peripheral eosinophil count ( < 0.05 for both). Moreover, the mean peripheral eosinophil count was significantly higher in the patients with high mucosal eosinophil count than in those with low mucosal eosinophil count ( < 0.05).
Mucosal and peripheral eosinophilia can be used as a marker to predict disease severity in nasal polyps.
尽管鼻息肉是最常见的疾病之一，但其发病机制仍不清楚。由于嗜酸性粒细胞是大部分鼻息肉组织中的主要炎症细胞，它们被认为可能与该疾病的发病机制和预后有关。本研究的目的是探讨鼻息肉中黏膜和外周血嗜酸性粒细胞增多之间的关系及其与疾病严重程度的关系。
该研究纳入了53例行鼻内镜鼻窦手术的鼻息肉患者。记录患者术前的Lund-MacKay计算机断层扫描（CT）评分和Lund-Kennedy内镜评分。鼻息肉组织用苏木精和伊红染色，在光学显微镜下使用高倍视野（HPF，400×）进行嗜酸性粒细胞计数，并将患者分为黏膜嗜酸性粒细胞计数高的患者和黏膜嗜酸性粒细胞计数低的患者。
黏膜嗜酸性粒细胞计数高的患者的平均Lund-MacKay CT评分和平均Lund-Kennedy内镜评分高于黏膜嗜酸性粒细胞计数低的患者。同样，外周血嗜酸性粒细胞计数高的患者的平均Lund-MacKay CT评分和平均Lund-Kennedy内镜评分显著高于外周血嗜酸性粒细胞计数低的患者（两者均P<0.05）。此外，黏膜嗜酸性粒细胞计数高的患者的平均外周血嗜酸性粒细胞计数显著高于黏膜嗜酸性粒细胞计数低的患者（P<0.05）。
黏膜和外周血嗜酸性粒细胞增多可作为预测鼻息肉疾病严重程度的标志物。
