Kumar Sanjay, Natraj Rashmi, Dutta Angshuman
Department of Ear, Nose, Throat - Head and Neck Surgery (ENT-HNS), Command Hospital Airforce, Bangalore, Karnataka 560007 India.
Indian J Otolaryngol Head Neck Surg. 2024 Dec;76(6):5602-5609. doi: 10.1007/s12070-024-05043-6. Epub 2024 Sep 6.
This study aimed to establish normative data for cervical (cVEMP) and ocular (oVEMP) vestibular evoked myogenic potentials in the Indian population, with a focus on assessing demographic variations across different age groups and genders. A cross-sectional observational study was conducted from January 2023 to December 2023 at a tertiary care center, involving 40 participants with normal hearing thresholds. Standardized cVEMP and oVEMP tests were performed using 500 Hz tone bursts at 95-115 dB nHL. VEMP responses, including latency and amplitude, were statistically analyzed using descriptive statistics, ANOVA, and Kruskal-Wallis tests to determine normative ranges and assess the impact of age and gender. The study established normative VEMP thresholds at about 105 dB for cervical (cVEMP) and ocular (oVEMP) responses, notably higher than the global average of 70-100 dB, suggesting unique regional variations in the Indian demographic. Normative values ranged from 45.68 at the 5th percentile to 92.32 at the 95th percentile for cVEMPs, and 13.12 to 18.58 for oVEMPs. Data analysis showed exceptionally stable VEMP responses with minimal age-related decline-significantly less than typically seen in Western populations, and no significant gender differences, indicating consistent vestibular function across diverse demographic groups. This research significantly enhances the diagnostic framework for vestibular disorders in India by establishing tailored normative VEMP data. These benchmarks facilitate precise clinical assessments and support the development of customized treatment protocols, improving healthcare outcomes for vestibular dysfunctions.
The online version contains supplementary material available at 10.1007/s12070-024-05043-6.
本研究旨在建立印度人群中颈肌（cVEMP）和眼肌（oVEMP）前庭诱发肌源性电位的标准数据，重点评估不同年龄组和性别的人口统计学差异。2023年1月至2023年12月在一家三级医疗中心进行了一项横断面观察性研究，纳入40名听力阈值正常的参与者。使用95 - 115 dB nHL的500 Hz短纯音进行标准化的cVEMP和oVEMP测试。使用描述性统计、方差分析和克鲁斯卡尔 - 沃利斯检验对VEMP反应（包括潜伏期和波幅）进行统计分析，以确定标准范围并评估年龄和性别的影响。该研究确定颈肌（cVEMP）和眼肌（oVEMP）反应的标准VEMP阈值约为105 dB，明显高于全球平均的70 - 100 dB，表明印度人口存在独特区域差异。cVEMPs的标准值范围为第5百分位数的45.68至第95百分位数的92.32，oVEMPs为13.12至18.58。数据分析显示VEMP反应异常稳定，与年龄相关的下降极小——明显低于西方人群的常见情况，且无显著性别差异，表明不同人口群体的前庭功能一致。本研究通过建立定制的标准VEMP数据，显著增强了印度前庭疾病的诊断框架。这些基准有助于精确的临床评估，并支持制定定制的治疗方案，改善前庭功能障碍的医疗结果。
在线版本包含可在10.1007/s12070 - 024 - 05043 - 6获取的补充材料。
