Vestibular Research Laboratory, School of Psychology, The University of Sydney, NSW, Australia.
Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Clin Neurophysiol. 2011 Mar;122(3):611-616. doi: 10.1016/j.clinph.2010.07.018. Epub 2010 Aug 14.
Intense air-conducted sound (ACS) elicits an ocular vestibular-evoked myogenic potential (oVEMP), and it has been suggested that it does so by stimulating saccular receptors and afferents in the inferior vestibular nerve and so activating a crossed sacculo-ocular pathway. Bone conducted vibration (BCV) also elicits an oVEMP probably by activating utricular receptors and a crossed utriculo-ocular pathway. Are there two separate pathways mediating oVEMPs for ACS and BCV? If saccular receptors and afferents are primarily responsible for the oVEMP to ACS, then the oVEMP to ACS should be normal in patients with reduced or absent utricular function--unilateral superior vestibular neuritis (SVN). If utricular receptors and afferents are primarily responsible for oVEMP n10, then oVEMP to ACS should be reduced or absent in SVN patients, and in these patients there should be a close relationship between the size of the oVEMP n10 to BCV and to ACS.
The n10 component of the oVEMP to 500 Hz BCV and to 500 Hz ACS was recorded in 10 patients with unilateral SVN but who had saccular and inferior vestibular nerve function preserved, as shown by their normal cVEMP responses to ACS.
In SVN patients with normal saccular and inferior vestibular nerve function, the oVEMP n10 in response to ACS was reduced or absent. Across SVN patients there was a very close correspondence between the size of oVEMP n10 for ACS and for BCV.
The n10 component of the oVEMP to ACS is probably mediated predominantly by the superior vestibular nerve and so most likely by utricular receptors and afferents.
The n10 component of the oVEMP to either ACS or BCV probably indicates mainly superior vestibular nerve function.
强烈的空气传导声音（ACS）会引发眼前庭诱发肌源性电位（oVEMP），有人认为它通过刺激囊状接收器和前庭下神经中的传入纤维来实现，从而激活交叉囊状眼动通路。骨传导振动（BCV）也会引发 oVEMP，可能是通过激活耳石受体和交叉耳石眼动通路。是否有两条独立的通路来介导 ACS 和 BCV 的 oVEMP？如果囊状感受器和传入纤维主要负责 ACS 的 oVEMP，那么单侧上前庭神经炎（SVN）患者的 ACS 诱发 oVEMP 应该是正常的。如果耳石受体和传入纤维主要负责 oVEMP n10，那么 SVN 患者的 ACS 诱发 oVEMP 应该减少或消失，并且在这些患者中，BCV 和 ACS 诱发 oVEMP n10 的大小之间应该存在密切关系。
记录了 10 例单侧 SVN 但保留了囊状和前庭下神经功能的患者对 500Hz BCV 和 500Hz ACS 的 oVEMP n10 成分。
在 SVN 患者中，具有正常的囊状和前庭下神经功能，ACS 诱发的 oVEMP n10 减少或消失。在 SVN 患者中，ACS 和 BCV 诱发的 oVEMP n10 大小之间存在非常密切的对应关系。
ACS 诱发的 oVEMP n10 成分可能主要由前庭上神经介导，因此很可能由耳石受体和传入纤维介导。
ACS 或 BCV 诱发的 oVEMP 的 n10 成分可能主要表明前庭上神经功能。
