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伴有小脑受累的鼻窦型抗中性粒细胞胞浆抗体阴性的肉芽肿性多血管炎

ANCA-Negative Granulomatosis of Polyngiitis of Paranasal Sinuses with Cerebellar Involvement.

作者信息

Mahmutoglu Abdullah Soydan, Duzkalir Hanife Gulden, Erdal Yuksel, Mahmutoglu Ozdes, Karagoz Yesim

机构信息

Department of Radiology, Istanbul Training and Research Hospital, Istanbul, Turkey.

Department of Radiology, Kartal Dr. Lütfü Kırdar Training and Research Hospital, Istanbul, Turkey.

出版信息

Indian J Otolaryngol Head Neck Surg. 2024 Dec;76(6):5944-5948. doi: 10.1007/s12070-024-05005-y. Epub 2024 Aug 27.

DOI:10.1007/s12070-024-05005-y
PMID:39559134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11569042/
Abstract

Granulomatosis of polyangiitis (GPA) is a multisystem necrotizing vasculitis, which affects small- and medium-sized blood vessels and characterized by frequent involvement of the upper and lower respiratory tract and kidneys. Altough anti-neutrophil cytoplasmic antibodies (ANCA) are higly associated with GPA and play an important role in the pathogenesis of this disease, ANCA positivity is not essential for clinical diagnosis. We describe a patient with ANCA-negative granulamatosis of polyangiitis involving cerebellum, having complaints due to sinusitis.

摘要

肉芽肿性多血管炎（GPA）是一种多系统坏死性血管炎，累及中小血管，以上下呼吸道和肾脏频繁受累为特征。虽然抗中性粒细胞胞浆抗体（ANCA）与GPA高度相关且在该疾病的发病机制中起重要作用，但ANCA阳性并非临床诊断所必需。我们描述了一名患有累及小脑的ANCA阴性肉芽肿性多血管炎患者，因鼻窦炎而出现症状。

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本文引用的文献

1
Granulomatosis with polyangiitis and facial palsy: Literature review and insight in the autoimmune pathogenesis.肉芽肿性多血管炎伴面瘫：文献复习及自身免疫发病机制的探讨。
Autoimmun Rev. 2016 Jul;15(7):621-31. doi: 10.1016/j.autrev.2016.02.005. Epub 2016 Feb 4.
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Granulomatosis with polyangiitis (Wegener): clinical aspects and treatment.肉芽肿性多血管炎（韦格纳）：临床特征和治疗。
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Diagnosis and classification of granulomatosis with polyangiitis (aka Wegener's granulomatosis).肉芽肿性多血管炎（又名韦格纳氏肉芽肿病）的诊断和分类。
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Otorhinolaryngological manifestations in granulomatosis with polyangiitis (Wegener's).肉芽肿性多血管炎（韦格纳氏）的耳鼻喉表现。
Autoimmun Rev. 2013 Feb;12(4):501-5. doi: 10.1016/j.autrev.2012.08.010. Epub 2012 Aug 23.
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Wegener's granulomatosis of the paranasal sinuses with orbital and central nervous system involvement-diagnostic imaging.鼻窦韦格纳肉芽肿伴眼眶和中枢神经系统受累的诊断影像学表现。
Acta Neurol Belg. 2011 Sep;111(3):241-4.
7
Patterns of presentation and diagnosis of patients with Wegener's granulomatosis: ENT aspects.韦格纳肉芽肿病患者的临床表现与诊断模式：耳鼻喉科方面
J Laryngol Otol. 2007 Jul;121(7):653-8. doi: 10.1017/S0022215106005032. Epub 2006 Dec 4.
8
Sinonasal computed tomography in patients with Wegener's granulomatosis.韦格纳肉芽肿病患者的鼻窦计算机断层扫描
J Comput Assist Tomogr. 2006 Jan-Feb;30(1):122-5. doi: 10.1097/01.rct.0000191134.67674.c6.
9
Head and neck manifestations of Wegener's granulomatosis.韦格纳肉芽肿的头颈部表现。
Otolaryngol Clin North Am. 2003 Aug;36(4):685-705. doi: 10.1016/s0030-6665(03)00023-9.
10
Rhinologic changes in Wegener's granulomatosis.韦格纳肉芽肿病的鼻科改变
J Laryngol Otol. 2002 Jul;116(7):565-9. doi: 10.1258/002221502760132737.