Sui Xinyao, Zhang Liyi, Xu Weiqing, Meng Xia, Zhao Yue, Gui Yuyan, Shi Huijing, Wang Pengpeng, Zhang Yunhui
Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China.
Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai 200032, China.
Eco Environ Health. 2024 May 8;3(4):436-444. doi: 10.1016/j.eehl.2024.04.008. eCollection 2024 Dec.
Prenatal ozone (O) exposure may disrupt normal offspring growth. However, epidemiological evidence that prenatal O exposure affects the physical development of offspring early in life is far from adequate. A total of 4909 maternal-child pairs from the Shanghai Maternal-Child Pairs Cohort were included. A high-resolution random forest model was utilized to evaluate prenatal exposure levels of O based on the home addresses of pregnant women. Group-based trajectory and mixed-effects models were used to assess associations between prenatal O exposure and physical parameters. Each 10 μg/m³ increase in O concentration was associated with 0.084, 0.048, and 0.082-unit increases in body mass index (BMI) for age Z score (BAZ), weight for age Z score (WAZ), and weight for length Z score (WLZ), respectively. Specifically, a 10 μg/m³ increase in O concentration was linked to a 1.208-fold and 1.209-fold increase in the elevated-increasing group for the BAZ and WLZ trajectories, respectively. Moreover, each 10 μg/m³ increases in prenatal O was associated with a 1.396-fold and 0.786-fold increase in the risk of BAZ- and length for age Z score (LAZ)-accelerated growth, respectively. Furthermore, a 10 μg/m³ increase in prenatal O was linked to a 1.355-fold increase in the risk of overweight and obesity (OAO). Our study revealed that prenatal O exposure is associated with accelerated BMI gain or decelerated body length gain in the early life of children. Prenatal O may also increase the risk of OAO in children for the first two years.
产前暴露于臭氧（O）可能会扰乱子代的正常生长。然而，关于产前暴露于臭氧会影响子代生命早期身体发育的流行病学证据还远远不足。本研究纳入了来自上海母婴队列的4909对母婴。基于孕妇的家庭住址，利用高分辨率随机森林模型评估产前臭氧暴露水平。采用基于群组的轨迹模型和混合效应模型来评估产前臭氧暴露与身体参数之间的关联。臭氧浓度每增加10μg/m³，年龄别体重指数（BAZ）、年龄别体重Z评分（WAZ）和身长别体重Z评分（WLZ）分别增加0.084、0.048和0.082个单位。具体而言，臭氧浓度每增加10μg/m³，BAZ和WLZ轨迹的上升增长组分别增加1.208倍和1.209倍。此外，产前臭氧每增加10μg/m³，BAZ加速增长和年龄别身长Z评分（LAZ）加速增长的风险分别增加1.396倍和0.786倍。此外，产前臭氧每增加10μg/m³，超重和肥胖（OAO）风险增加1.355倍。我们的研究表明，产前暴露于臭氧与儿童生命早期BMI加速增加或身长增长减速有关。产前暴露于臭氧还可能增加儿童头两年患OAO的风险。
