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慢性咳嗽作为一种疾病。

Chronic cough as a disease.

作者信息

Turner Richard D, Birring Surinder S

机构信息

Princess Alexandra Hospital, Brisbane, Australia.

School of Medicine and Dentistry, Griffith University, Southport, Australia.

出版信息

ERJ Open Res. 2024 Nov 18;10(6). doi: 10.1183/23120541.00459-2024. eCollection 2024 Nov.

Abstract

Chronic cough is a frequent reason for medical consultation and has significant impact on quality of life. Due to the limited effectiveness of currently available treatments, and delays in accessing care, patients are often inadequately managed. There remains an overreliance by clinicians on outdated management algorithms, addressing chronic cough only as symptom of other medical conditions, and advocating investigation and trials of treatment of diseases which are often not present. This may lead to unnecessary cost, frustration and potential harm. Newer clinical guidelines in essence consider chronic cough as a disease in itself, resulting from afferent neuronal hypersensitivity and central nervous system dysfunction. Secondary factors which aggravate chronic cough (smoking, asthma, gastro-oesophageal reflux, ) are better considered as treatable traits associated with the primary disease process rather than direct "causes" of cough. Explicitly approaching chronic cough as a discrete entity is consistent with the way in which "diseases" are generally characterised, and has advantages. The patient should be better able to understand their condition, and may have better confidence in attempts at management. The clinician should have better focus and avoid unfruitful treatments and investigation. In general, considering chronic cough as a disease should help to raise the profile of the condition, improve organisation of health service pathways, increase attention for research, and further the development of new treatments.

摘要

慢性咳嗽是患者寻求医疗咨询的常见原因,对生活质量有重大影响。由于现有治疗方法效果有限,且获得治疗存在延迟,患者往往得不到充分的管理。临床医生仍然过度依赖过时的管理算法,仅将慢性咳嗽视为其他疾病的症状,并主张对往往并不存在的疾病进行检查和治疗试验。这可能导致不必要的费用、患者的沮丧以及潜在危害。最新的临床指南本质上认为慢性咳嗽本身就是一种疾病,是由传入神经元超敏反应和中枢神经系统功能障碍引起的。加重慢性咳嗽的次要因素(吸烟、哮喘、胃食管反流等)最好被视为与主要疾病过程相关的可治疗特征,而非咳嗽的直接“病因”。将慢性咳嗽明确视为一个独立的实体,与“疾病”的一般特征相符,且具有优势。患者应能更好地理解自身病情,对治疗尝试可能更有信心。临床医生应更有针对性,避免进行无果的治疗和检查。总体而言,将慢性咳嗽视为一种疾病应有助于提高该病症的受关注程度,改善医疗服务途径的组织,增加对研究的关注,并推动新治疗方法的开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1482/11571073/451a92d66bd4/00459-2024.01.jpg

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