In a patient with a history of lumbar spine surgery, the management of refractory low back pain may prove challenging. Advancing neuromodulatory techniques and technologies offer the promise of significant and sustained relief in these patients, though prior literature is limited. We present a case of peripheral nerve stimulation at the lumbar medial branches in a woman with chronic axial low back pain following a three-level laminectomy. Six months after the sequential bilateral treatment, the patient reported complete relief of her low back pain, increased activity, and a significant reduction in oral medication burden.