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多花木蓝对7,12-二甲基苯并[a]蒽诱导的仓鼠颊囊癌变过程中诱导型一氧化氮合酶表达的影响。

Effect of Indigofera aspalathoides on the Expression of Inducible Nitric Oxide Synthase During 7,12-Dimethylbenz[a]anthracene-Induced Hamster Buccal Pouch Carcinogenesis.

作者信息

Abraham Philips, Philip Sachu, Azad Mohammed Salman, Mohammed Unni Hafsa

机构信息

Department of Biochemistry, Al Azhar Medical College Hospitals and Research Institute, Thodupuzha, IND.

Department of Biochemistry, Swamy Vivekanandha Medical College Hospitals and Research Institute, Namakkal, IND.

出版信息

Cureus. 2024 Oct 19;16(10):e71841. doi: 10.7759/cureus.71841. eCollection 2024 Oct.

DOI:10.7759/cureus.71841
PMID:39559675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11571105/
Abstract

BACKGROUND

The mechanisms of inflammation and carcinogenesis are significantly influenced by nitric oxide (NO). Three different kinds of nitric oxide synthase (NOS) have been previously found: neuronal NOS, inducible nitric oxide synthase (iNOS), and endothelial NOS.

OBJECTIVES

This study looked into the properties of iNOS in hamster buccal pouch carcinogenesis caused by 7,12-dimethylbenz[a]anthracene (DMBA).

METHODS

Thirty outbred young male Syrian golden hamsters, aged six weeks, were split into five groups at random: control (n=6), administered with ethanolic extract (n=6), DMBA+EIA (ethanolic Indigofera aspalathoides) (n=6), 0.5% solution of DMBA in liquid paraffin (n=6), and DMBA alone (n=6).

RESULT

In the group treated with DMBA, the mean quantity of iNOS positive foci per section was roughly 12.2+/-4.7. The DMBA-treated pouch keratinocytes showed both nuclear and cytoplasmic stainings. Neither the mineral oil-treated nor the untreated pouches (n=10) showed any signs of iNOS activity.

CONCLUSION

In conclusion, this work has shown that hamster pouch carcinomas induced by DMBA express iNOS. This finding raises the possibility that the emergence of chemically induced oral carcinomas is linked to iNOS expression.

摘要

背景

一氧化氮（NO）对炎症和致癌作用的机制有显著影响。先前已发现三种不同类型的一氧化氮合酶（NOS）：神经元型NOS、诱导型一氧化氮合酶（iNOS）和内皮型NOS。

目的

本研究探讨了iNOS在7,12 - 二甲基苯并[a]蒽（DMBA）诱导的仓鼠颊囊癌变中的特性。

方法

将30只六周龄的远交系年轻雄性叙利亚金仓鼠随机分为五组：对照组（n = 6），给予乙醇提取物（n = 6），DMBA + EIA（乙醇提取物紫穗槐）（n = 6），0.5% DMBA液体石蜡溶液（n = 6），以及单独使用DMBA（n = 6）。

结果

在DMBA处理组中，每切片iNOS阳性灶的平均数量约为12.2±4.7。经DMBA处理的颊囊角质形成细胞显示出细胞核和细胞质染色。经矿物油处理的颊囊和未处理的颊囊（n = 10）均未显示出任何iNOS活性迹象。

结论

总之，本研究表明DMBA诱导的仓鼠颊囊癌表达iNOS。这一发现增加了化学诱导的口腔癌的发生与iNOS表达有关的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed2/11571105/83b4d2099075/cureus-0016-00000071841-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed2/11571105/b6ff205b1198/cureus-0016-00000071841-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed2/11571105/645a41c7ad97/cureus-0016-00000071841-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed2/11571105/f1a7e60e5c61/cureus-0016-00000071841-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed2/11571105/5330a990912a/cureus-0016-00000071841-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed2/11571105/83b4d2099075/cureus-0016-00000071841-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed2/11571105/b6ff205b1198/cureus-0016-00000071841-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed2/11571105/645a41c7ad97/cureus-0016-00000071841-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed2/11571105/f1a7e60e5c61/cureus-0016-00000071841-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed2/11571105/5330a990912a/cureus-0016-00000071841-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed2/11571105/83b4d2099075/cureus-0016-00000071841-i05.jpg

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