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丹麦国家医院药物登记册:药物流行病学的一个资源。

The Danish National Hospital Medication Register: A Resource for Pharmacoepidemiology.

作者信息

Rosenkrantz Oscar, Wheler Jannik, Westphal Thrane Mats Christian, Pedersen Lars, Sørensen Henrik Toft

机构信息

Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University Hospital and Aarhus University, Aarhus, Denmark.

Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark.

出版信息

Clin Epidemiol. 2024 Nov 14;16:783-792. doi: 10.2147/CLEP.S487838. eCollection 2024.

Abstract

BACKGROUND

The Danish National Hospital Medication Register (DHMR), one of the first nationwide in-hospital medication registries in the world, contains detailed information on medication administration and dispensing.

OBJECTIVE

To provide an overview of the information recorded in the DHMR and to highlight its strengths and limitations as a pharmacoepidemiological research tool.

METHODS

We reviewed the registry´s geographic and clinical specialty coverage and medications recorded according to the main groups of the Anatomical Therapeutic Chemical classification system.

RESULTS

From May 2018 through December 2023, the DHMR recorded data on more than 1.9 million unique patients from all approximately 50 public hospitals and associated hospital outpatient clinics, totaling 105.3 million recordings of hospital medication use. The registry records detailed data on the indication for medication, medication type, pharmaceutical form, dosage, and administration time, collected through electronic medical record systems. Although the data quality has not yet been evaluated in a scientific context, some potential limitations are known. These include regional differences in the data collection and a lack of data from certain clinical specialties. Due to its recent establishment in 2018, the registered number of patients treated may still be limited for some rarely used medications.

CONCLUSION

The DHMR is an important new resource for research in Denmark. Combined with the Danish National Prescription Registry, which covers all community pharmacies, it offers access to accurate data on medication exposure in the Danish population. Users should be aware of potential issues with lack of information before 2018.

摘要

背景

丹麦国家医院药物登记册(DHMR)是世界上最早的全国性医院药物登记册之一,包含药物给药和配药的详细信息。

目的

概述DHMR中记录的信息,并突出其作为药物流行病学研究工具的优势和局限性。

方法

我们审查了该登记册的地理和临床专科覆盖范围,以及根据解剖治疗化学分类系统的主要类别记录的药物。

结果

从2018年5月到2023年12月,DHMR记录了来自约50家公立医院及相关医院门诊的190多万名独特患者的数据,医院药物使用记录总计1.053亿条。该登记册通过电子病历系统记录有关用药指征、药物类型、剂型、剂量和给药时间的详细数据。尽管尚未在科学背景下对数据质量进行评估,但已知一些潜在局限性。这些包括数据收集的地区差异以及某些临床专科的数据缺失。由于其于2018年才建立,对于一些很少使用的药物,登记的治疗患者数量可能仍然有限。

结论

DHMR是丹麦研究的一项重要新资源。与涵盖所有社区药房的丹麦国家处方登记册相结合,它提供了获取丹麦人群药物暴露准确数据的途径。用户应注意2018年之前可能存在的信息缺失问题。

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The Danish National Prescription Registry.丹麦国家处方登记处。
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