Sørensen H T, Larsen B O
Department of Internal Medicine V, Aarhus University Hospital, Denmark.
J Med Syst. 1994 Feb;18(1):33-8. doi: 10.1007/BF00999322.
The incomplete understanding of drug effects at the time of marketing has led to ongoing epidemiological monitoring. The Danish National Health Service covers part of the expenses for most kinds of prescription drugs. The accounting system within the pharmacies is increasingly computerized. In 1992 we found that 96% of the pharmacies were computerized. The computerized accounting systems give no information about adverse drug effects, but this can be obtained from the Danish Hospital Register by cross-checking registries, and in some cases from the register of birth and the register of congenital malformations. There is a great need for new data sources in pharmacoepidemiology. In spite of some evident methodological problems, the Danish data sources probably have high validity compared with international sources, since they are population based.
药品上市时对其效果的不完全了解导致了持续的流行病学监测。丹麦国家医疗服务体系承担了大部分处方药的部分费用。药店内部的会计系统越来越多地实现了计算机化。1992年我们发现96%的药店已实现计算机化。计算机化的会计系统无法提供药物不良反应的信息，但可通过交叉核对登记处从丹麦医院登记册获取，在某些情况下还可从出生登记册和先天性畸形登记册获取。药物流行病学非常需要新的数据来源。尽管存在一些明显的方法学问题，但丹麦的数据来源与国际来源相比可能具有较高的有效性，因为它们是以人群为基础的。
