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马来西亚无刺蜂蜂胶的化学成分及药理学研究:最新系统综述

Chemical composition and pharmacological aspects of Malaysian stingless bee propolis: An up‑to‑date systematic review.

作者信息

Jusril Nor Atiqah, Mohd Khamsah Suryati, Abd Mutalib Nurliana, Mohd Badiazaman Ainur Awanis

机构信息

School of Agriculture Science and Biotechnology, Faculty of Bioresources and Food Industry, Universiti Sultan Zainal Abidin, Besut Campus, 22200 Besut, Terengganu Darul Iman, Malaysia.

Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Level 9, FF3 Puncak Alam Campus, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor Darul Ehsan, Malaysia.

出版信息

Biomed Rep. 2024 Nov 5;22(1):9. doi: 10.3892/br.2024.1887. eCollection 2025 Jan.

DOI:10.3892/br.2024.1887
PMID:39559820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11572029/
Abstract

Propolis is a sticky substance produced by stingless bees for construction and defence of their hive. It has notable anti-inflammatory, antioxidant, antibacterial, antifungal, anti-hyperglycemic, and wound healing effects. The present review summarised and examined the phytochemical properties, mode of action and current research prospects of Malaysian propolis. A database search using Google Scholar, Web of Science and ScienceDirect generated 780 references; 30 relevant articles were included in the present review, of which 23 were studies and 7 were or animal studies. Propolis demonstrated antioxidant, antibacterial, antifungal, anti-inflammatory and anti-hyperglycemic properties, indicating potential as a wound healing agent. Despite favourable findings, due to the scarcity of studies in the literature, more in-depth research and clinical validation on the synergistic effects, efficacy and optimum dosage of propolis are needed.

摘要

蜂胶是一种由无刺蜂产生的粘性物质,用于建造和保卫蜂巢。它具有显著的抗炎、抗氧化、抗菌、抗真菌、抗高血糖和伤口愈合作用。本综述总结并研究了马来西亚蜂胶的植物化学特性、作用方式和当前的研究前景。通过谷歌学术、科学网和科学Direct进行数据库搜索,共获得780篇参考文献;本综述纳入了30篇相关文章,其中23篇为研究报告,7篇为综述或动物研究。蜂胶具有抗氧化、抗菌、抗真菌、抗炎和抗高血糖特性,表明其具有作为伤口愈合剂的潜力。尽管有这些有利的研究结果,但由于文献中研究较少,仍需要对蜂胶的协同作用、疗效和最佳剂量进行更深入的研究和临床验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7f5/11572029/7df20fe79e5d/br-22-01-01887-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7f5/11572029/08c8125d1907/br-22-01-01887-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7f5/11572029/c21c7e1af852/br-22-01-01887-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7f5/11572029/7df20fe79e5d/br-22-01-01887-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7f5/11572029/08c8125d1907/br-22-01-01887-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7f5/11572029/c21c7e1af852/br-22-01-01887-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7f5/11572029/7df20fe79e5d/br-22-01-01887-g02.jpg

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本文引用的文献

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Pharmaceuticals (Basel). 2023 May 7;16(5):712. doi: 10.3390/ph16050712.
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Q-TOF LC-MS compounds evaluation of propolis extract derived from Malaysian stingless bees, , and their bioactivities in breast cancer cell, MCF7.马来西亚无刺蜂源蜂胶提取物的Q-TOF LC-MS化合物评估及其在乳腺癌细胞MCF7中的生物活性
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Determination of Total Phenolics, Flavonoids, and Antioxidant Activity and GC-MS Analysis of Malaysian Stingless Bee Propolis Water Extracts.马来西亚无刺蜂蜂胶水提取物中总酚、黄酮类化合物的测定、抗氧化活性及气相色谱-质谱分析
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Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study.通过分子对接研究探讨乙醇蜂胶提取物对 COVID-19 治疗中 ACE-II 受体的潜在抑制特性。
Arch Microbiol. 2021 Aug;203(6):3557-3564. doi: 10.1007/s00203-021-02351-1. Epub 2021 May 5.
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BMC Med Res Methodol. 2021 Apr 30;21(1):94. doi: 10.1186/s12874-021-01281-2.
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