Dong Young Lee, Department of Neuropsychiatry, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea; Telephone: +82-2-2072-2205, Fax: +82-2-744-2471, Email:
J Prev Alzheimers Dis. 2024;11(6):1767-1774. doi: 10.14283/jpad.2024.131.
This study investigates the synergistic relationship between blood low-density lipoprotein cholesterol (LDL-C) and cerebral beta-amyloid (Aβ) in relation to tau deposition, a key factor in the pathology of Alzheimer's disease (AD), in older adults across a diverse cognitive spectrum.
To examine whether higher levels of LDL-C in the blood moderate the association of cerebral Aβ with tau deposition in older adults, including those with normal cognition, mild cognitive impairment, and Alzheimer's disease dementia.
Cross-sectional design.
The study was conducted as a part of a prospective cohort study. All assessments were done at the Seoul National University Hospital, Seoul, South Korea.
A total of 136 older adults (aged 60-85 years) with normal cognition, mild cognitive impairment or Alzheimer's disease (AD) dementia were included.
Serum lipid measurements, [11C] Pittsburgh Compound B-positron emission tomography (PET), [18F] AV-1451 PET, and magnetic resonance imaging were performed on all participants.
There was a significant Aβ x LDL-C interaction effect on tau deposition indicating a synergistic moderation effect of LDL-C on the relationship between Aβ and tau deposition. Subsequent subgroup analysis showed that the positive association between Aβ and tau deposition was stronger in higher LDL-C group than in lower LDL-C group. In contrast, other lipids, such as total cholesterol, high-density lipoprotein cholesterol, and triglycerides, did not show a similar moderation effect on the relationship between Aβ deposition and tau deposition.
Our findings suggest that blood LDL-C synergistically enhances the influence of Aβ deposition on tau pathology, emphasizing the need for greater attention to the role of LDL-C in AD progression.
本研究调查了血液中低密度脂蛋白胆固醇（LDL-C）与脑β-淀粉样蛋白（Aβ）之间的协同关系，以及它们与tau 沉积的关系，tau 沉积是阿尔茨海默病（AD）病理学中的一个关键因素，涉及认知范围广泛的老年人。
研究血液中 LDL-C 水平是否会调节大脑 Aβ 与 tau 沉积在老年人中的关联，包括认知正常、轻度认知障碍和 AD 痴呆的老年人。
横断面设计。
本研究作为一项前瞻性队列研究的一部分进行。所有评估均在韩国首尔国立大学医院进行。
共纳入 136 名年龄在 60-85 岁之间认知正常、轻度认知障碍或 AD 痴呆的老年人。
对所有参与者进行血清脂质测量、[11C]匹兹堡复合物 B-正电子发射断层扫描（PET）、[18F] AV-1451 PET 和磁共振成像。
tau 沉积存在 Aβ x LDL-C 交互作用效应，表明 LDL-C 对 Aβ 和 tau 沉积之间关系具有协同调节作用。随后的亚组分析表明，Aβ 与 tau 沉积之间的正相关在 LDL-C 较高的组中比在 LDL-C 较低的组中更强。相比之下，其他脂质，如总胆固醇、高密度脂蛋白胆固醇和甘油三酯，对 Aβ 沉积与 tau 沉积之间的关系没有类似的调节作用。
我们的研究结果表明，血液 LDL-C 协同增强了 Aβ 沉积对 tau 病理学的影响，强调需要更加关注 LDL-C 在 AD 进展中的作用。
