Cui Liang, Zhang Zhen, Tu You-Yi, Wang Min, Guan Yi-Hui, Li Yue-Hua, Xie Fang, Guo Qi-Hao
Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
School of Life Sciences, Shanghai University, Shanghai, China.
Alzheimers Dement. 2025 Jan;21(1):e14380. doi: 10.1002/alz.14380. Epub 2024 Nov 19.
It remains unclear whether the local amyloid-beta (Aβ) burden in key regions within the default mode network (DMN) affects network and cognitive functions.
Participants included 1002 individuals from the Chinese Preclinical Alzheimer's Disease Study cohort who underwent 18F-florbetapir positron emission tomography resting-state functional magnetic resonance imaging scanning and neuropsychological tests. The correlations between precuneus (PRC) Aβ burden, DMN function, and cognitive function were investigated.
In individuals with high PRC Aβ burden, there is a bidirectional relationship between DMN local function or functional connectivity and PRC Aβ deposition across various cognitive states, which is also linked to cognitive function. Even below the PRC Aβ threshold, DMN function remains related to PRC Aβ deposition and cognitive performance.
The findings reveal the critical role of PRC Aβ deposition in disrupting neural networks associated with cognitive decline and the necessity of early detection and monitoring of PRC Aβ deposition.
Precuneus (PRC) Aβ burden impacts DMN function in different cognitive stages. High PRC Aβ burden is linked to early neural compensation and subsequent dysfunction. Low PRC Aβ burden correlates with neural changes before significant Aβ accumulation. Changes in DMN function and connectivity provide insights into AD progression. Early detection of regional Aβ burden can help monitor the risk of cognitive decline.
目前尚不清楚默认模式网络（DMN）关键区域内的局部β-淀粉样蛋白（Aβ）负荷是否会影响网络和认知功能。
参与者包括来自中国临床前阿尔茨海默病研究队列的1002名个体，他们接受了18F-氟代贝他吡正电子发射断层扫描静息态功能磁共振成像扫描和神经心理学测试。研究了楔前叶（PRC）Aβ负荷、DMN功能和认知功能之间的相关性。
在PRC Aβ负荷高的个体中，DMN局部功能或功能连接与PRC Aβ在各种认知状态下的沉积之间存在双向关系，这也与认知功能相关。即使低于PRC Aβ阈值，DMN功能仍与PRC Aβ沉积和认知表现相关。
研究结果揭示了PRC Aβ沉积在破坏与认知衰退相关的神经网络中的关键作用，以及早期检测和监测PRC Aβ沉积的必要性。
楔前叶（PRC）Aβ负荷在不同认知阶段影响DMN功能。高PRC Aβ负荷与早期神经代偿及随后的功能障碍有关。低PRC Aβ负荷与Aβ大量积累之前的神经变化相关。DMN功能和连接性的变化为阿尔茨海默病进展提供了见解。早期检测区域Aβ负荷有助于监测认知衰退风险。
