睡眠可调节丘脑底核中刺激诱发的共振神经活动。
Stimulation-Evoked Resonant Neural Activity in the Subthalamic Nucleus Is Modulated by Sleep.
作者信息
Wiest Christoph, Simpson Thomas G, Pogosyan Alek, Hasegawa Harutomo, He Shenghong, Plazas Fernando Rodriguez, Wehmeyer Laura, Yassine Sahar, Guo Xuanjun, Shah Rahul, Merla Anca, Perera Andrea, Raslan Ahmed, O'Keeffe Andrew, Hart Michael G, Morgante Francesca, Pereira Erlick A, Ashkan Keyoumars, Tan Huiling
机构信息
Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Department of Neurosurgery, King's College Hospital, London, United Kingdom.
出版信息
Mov Disord. 2025 Feb;40(2):351-356. doi: 10.1002/mds.30063. Epub 2024 Nov 19.
BACKGROUND
Deep brain stimulation is a treatment for advanced Parkinson's disease and currently tuned to target motor symptoms during daytime. Parkinson's disease is associated with multiple nocturnal symptoms such as akinesia, insomnia, and sleep fragmentation, which may require adjustments of stimulation during sleep for best treatment outcome.
OBJECTIVES
There is a need for a robust biomarker to guide stimulation titration across sleep stages. This study aimed to investigate whether evoked resonant neural activity (ERNA) is modulated by sleep.
METHODS
We recorded local field potentials from the subthalamic nucleus of four Parkinson's patients with externalized electrodes while applying single stimulation pulses to investigate the effect of sleep on ERNA.
RESULTS
We found that ERNA features change with wakefulness and sleep stages and are correlated with canonical frequency bands and heart rate.
CONCLUSIONS
Given that ERNA modulates with sleep, it could be used as a robust marker for automatic stimulation titration during sleep. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
背景
深部脑刺激是治疗晚期帕金森病的一种方法，目前主要针对白天的运动症状进行调整。帕金森病与多种夜间症状有关，如运动不能、失眠和睡眠片段化，可能需要在睡眠期间调整刺激以获得最佳治疗效果。
目的
需要一种可靠的生物标志物来指导不同睡眠阶段的刺激滴定。本研究旨在调查诱发共振神经活动（ERNA）是否受睡眠调节。
方法
我们在4名帕金森病患者的丘脑底核通过外置电极记录局部场电位，同时施加单个刺激脉冲，以研究睡眠对ERNA的影响。
结果
我们发现ERNA特征随清醒和睡眠阶段而变化，并且与标准频段和心率相关。
结论
鉴于ERNA受睡眠调节，它可作为睡眠期间自动刺激滴定的可靠标志物。© 2024作者。《运动障碍》由Wiley Periodicals LLC代表国际帕金森和运动障碍协会出版。
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