Lagey C L, Roelofs J M, Janssen L W, Breedijk M, Lentferink R H, Visser W J, Akkermans L M, Wittebol P, Renooij W
Clin Orthop Relat Res. 1986 Mar(204):303-12.
Electrical stimulation of osteogenesis was studied in rabbit femora in: (A) a transcortical electric field with a cortex-depolarizing or hyperpolarizing orientation derived from an intramedullary electrode and a ring-shaped counter electrode encircling the femoral shaft; and (B) an electric field derived from an electrode located in the medullary canal and the counter electrode in the abdominal wall. Electrodes were made of platinum. A direct current of 20 microA was applied during six weeks. Contralateral femora with dummy electrodes served as controls. Results were analyzed by optical densitometry of roentgenograms and histomorphometry of histologic slides. Under the conditions of these experiments bone growth was not stimulated by applying a cortex-depolarizing electric field. Significant stimulation of bone growth was only observed at an intramedullary cathode, when the anode was placed at a distance.
在兔股骨中研究了电刺激成骨作用，具体如下：(A) 经皮质电场，其具有由髓内电极和环绕股骨干的环形反电极产生的皮质去极化或超极化方向；以及 (B) 由位于髓管内的电极和腹壁内的反电极产生的电场。电极由铂制成。在六周内施加20微安的直流电。带有假电极的对侧股骨用作对照。通过X线照片的光密度测定法和组织学切片的组织形态计量学分析结果。在这些实验条件下，施加皮质去极化电场不会刺激骨生长。仅当阳极放置在一定距离处时，在髓内阴极处才观察到对骨生长的显著刺激。
