Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Hum Exp Toxicol. 2024 Jan-Dec;43:9603271241302208. doi: 10.1177/09603271241302208.
Until now, no definite standardized method has been used to promptly assess the severity and outcome of acute aluminum phosphide (ALP) poisoning. The current study aimed to evaluate the performance of the new Poisoning Mortality Score (PMS) and PGI score for predicting mortality in acute ALP-poisoned patients, highlighting the accuracy of new PMS components.
A 2-year cross-sectional study was conducted on ALP-poisoned patients admitted to Tanta University Poison Control Centre from April 2021 to March 2023. Socio-demographics, poisoning data, and initial vital signs were recorded. Additionally, new PMS and PGI scores were calculated on admission. Patients were categorized according to the mortality outcome into survivors and nonsurvivors.
Out of 160 included ALP poisoned patients, mortality was recorded in 112 (70%) patients. The nonsurvivors had significantly higher median PGI and new PMS values than survivors. New PMS, vital signs component of new PMS, and PGI conveyed good discriminatory power for predicting mortality (AUC = 0.883, 0.873, and 0.817, respectively). Although the new PMS outperformed PGI in all predictive metrics, no significant difference in AUCs was observed between the new PMS and its vital signs component.
The new PMS vital signs component is closely aligned with the new PMS. Thus, it can be used as a valid, comprehensive, and practical tool to substitute the whole score calculation for rapid ALP-poisoned patient assessment to enhance emergency clinical decision-making.
到目前为止，还没有明确的标准化方法可以及时评估急性磷化铝（ALP）中毒的严重程度和结局。本研究旨在评估新的中毒死亡率评分（PMS）和 PGI 评分对预测急性 ALP 中毒患者死亡率的性能，突出新 PMS 成分的准确性。
对 2021 年 4 月至 2023 年 3 月在坦塔大学中毒控制中心收治的急性 ALP 中毒患者进行了为期 2 年的横断面研究。记录了社会人口统计学、中毒数据和初始生命体征。此外，入院时计算了新的 PMS 和 PGI 评分。根据死亡率将患者分为幸存者和非幸存者。
在纳入的 160 例 ALP 中毒患者中，有 112 例（70%）患者死亡。非幸存者的 PGI 和新 PMS 中位数明显高于幸存者。新 PMS、新 PMS 的生命体征成分和 PGI 对预测死亡率具有良好的区分能力（AUC=0.883、0.873 和 0.817）。虽然新 PMS 在所有预测指标上均优于 PGI，但新 PMS 及其生命体征成分的 AUC 之间无显著差异。
新 PMS 的生命体征成分与新 PMS 密切相关。因此，它可以作为一种有效的、全面的、实用的工具，替代整个评分计算，用于快速评估急性 ALP 中毒患者，以增强紧急临床决策。
