Xu Yujing, Sutanto Clarinda Nataria, Xia Xuejuan, Toh Darel Wee Kiat, Gan Alicia Xinli, Deng Qiyun, Ling Lieng Hsi, Khoo Chin Meng, Foo Roger Sik-Yin, Kim Jung Eun
Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore.
Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Nutr Metab Cardiovasc Dis. 2025 Jan;35(1):103773. doi: 10.1016/j.numecd.2024.10.011. Epub 2024 Oct 16.
BACKGROUND & AIMS: Plant sterols (PS) have been shown to lower blood lipid-lipoproteins concentrations and may serve as a potential functional ingredient for cardiovascular disease (CVD) risk management. However, there are limited studies examining this effect in individuals with metabolic syndrome (MetS). The aim of this study was to evaluate the effects of PS-enriched food consumption as part of a healthy dietary pattern (HDP) on blood pressure and endothelial function in Singaporean adults with MetS.
This was a 12-week, crossover, randomized controlled trial with a 4-week washout period. Thirteen subjects were instructed to consume an HDP diet either with normal soy milk (control group) or with PS (2 g/day)-enriched soy milk (PS group) for 4 weeks. Blood lipid-lipoproteins and glucose concentrations, blood pressure, and endothelial function-related indicators (flow-mediated dilation, total plasma nitrate/nitrite and endothelin-1, circulating endothelial progenitor cells) were assessed before and after the intervention. Systolic blood pressure [mean change, PS group: -4.0 ± 3.7 mmHg; control group: 5.9 ± 2.5 mmHg (P = 0.01)] and long-term CVD risk [mean change, PS group: -0.2 ± 1.0 %; control group: 2.7 ± 1.3 % (P = 0.03)] decreased following PS consumption. No changes were observed in the other endothelial function-related outcomes.
Consumption of PS-enriched food with an HDP diet may lower blood pressure and long-term CVD risk in adults with MetS.
NCT03723330, https://clinicaltrials.gov/.
植物甾醇（PS）已被证明可降低血脂 - 脂蛋白浓度，可能是心血管疾病（CVD）风险管理的潜在功能成分。然而，针对代谢综合征（MetS）患者进行此效应研究的文献有限。本研究旨在评估富含PS的食物作为健康饮食模式（HDP）的一部分，对新加坡患有MetS的成年人血压和内皮功能的影响。
这是一项为期12周的交叉随机对照试验，有4周的洗脱期。13名受试者被要求食用HDP饮食，一组饮用普通豆浆（对照组），另一组饮用富含PS（2克/天）的豆浆（PS组），为期4周。在干预前后评估血脂 - 脂蛋白和血糖浓度、血压以及内皮功能相关指标（血流介导的血管舒张、血浆总硝酸盐/亚硝酸盐和内皮素 - 1、循环内皮祖细胞）。食用PS后，收缩压[平均变化，PS组：-4.0±3.7 mmHg；对照组：5.9±2.5 mmHg（P = 0.01）]和长期CVD风险[平均变化，PS组：-0.2±1.0%；对照组：2.7±1.3%（P = 0.03）]降低。其他内皮功能相关指标未观察到变化。
在HDP饮食中食用富含PS的食物可能会降低患有MetS的成年人的血压和长期CVD风险。
NCT03723330，https://clinicaltrials.gov/ 。
