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基于多核苷酸的各种面部瘢痕治疗方法,包括战斗损伤。

Polynucleotide-based treatments for various facial scars including combat injuries.

机构信息

Aeon Medical and Aesthetic Centre, Singapore, Singapore.

Asia-Pacific Aesthetic Academy, Hong Kong, People's Republic of China.

出版信息

J Dermatolog Treat. 2024 Dec;35(1):2426626. doi: 10.1080/09546634.2024.2426626. Epub 2024 Nov 19.

DOI:10.1080/09546634.2024.2426626
PMID:39561983
Abstract

INTRODUCTION

This study examines the therapeutic efficacy of polynucleotide-based therapies, specifically REJURAN, for managing scars and burns. Scars and burns present significant challenges in dermatology, often affecting patients' quality of life. Traditional treatments can be limited in effectiveness, prompting the exploration of innovative approaches like polynucleotide therapy, which utilizes salmon DNA to stimulate tissue repair, modulate inflammation, and enhance collagen production.

METHODS

A series of case studies was conducted, including diverse patient profiles with various types of scars and burns. The study evaluated the impact of REJURAN on scar appearance, texture, and overall skin quality. Some cases also explored the combination of polynucleotide therapy with other treatments such as Platelet-Rich Plasma (PRP) and botulinum toxin.

RESULTS

Notable improvements were observed across cases, including reduced scar visibility and enhanced skin texture. The therapy proved effective in treating post-traumatic, post-operative, and burn-related scars, demonstrating its versatility and potential benefits. Combination therapies showed promising results, though further research is needed.

CONCLUSION

Polynucleotide-based therapy with REJURAN shows promise in scar and burn management, offering a novel approach that leverages the body's regenerative processes. Further studies are recommended to confirm these findings and refine treatment protocols.

摘要

简介

本研究探讨了基于多核苷酸的治疗方法,特别是 REJURAN,在治疗疤痕和烧伤方面的疗效。疤痕和烧伤是皮肤科的重大挑战,常影响患者的生活质量。传统治疗方法可能效果有限,因此需要探索创新方法,如多核苷酸治疗,该方法利用鲑鱼 DNA 刺激组织修复、调节炎症和促进胶原蛋白生成。

方法

进行了一系列病例研究,包括具有各种类型疤痕和烧伤的不同患者。研究评估了 REJURAN 对疤痕外观、质地和整体皮肤质量的影响。一些病例还探讨了将多核苷酸治疗与富血小板血浆 (PRP) 和肉毒杆菌毒素等其他治疗方法相结合的效果。

结果

在各病例中观察到显著改善,包括疤痕可见度降低和皮肤质地改善。该疗法在治疗创伤后、手术后和烧伤相关的疤痕方面效果显著,证明其具有多功能性和潜在益处。联合疗法显示出有前景的结果,但仍需要进一步研究。

结论

基于多核苷酸的 REJURAN 治疗在疤痕和烧伤管理方面显示出前景,提供了一种利用身体再生过程的新方法。建议进行进一步研究以确认这些发现并改进治疗方案。

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