Edwards J D, Kishen R
Crit Care Med. 1986 Apr;14(4):280-2. doi: 10.1097/00003246-198604000-00005.
In a heterogeneous group of 23 critically ill patients with recurrent and intractable bouts of supraventricular arrhythmia, increases in pulmonary artery wedge pressure significantly decreased cardiac output and exacerbated respiratory failure. Most patients were eventually stabilized on a long-term iv infusion of the calcium antagonist verapamil which, with appropriate monitoring, was well tolerated. We suggest that the use of verapamil infusion may play a significant role in the management of such patients and that further studies are justified.
在一组23例患有复发性和顽固性室上性心律失常的重症患者中，肺动脉楔压升高显著降低心输出量并加重呼吸衰竭。大多数患者最终通过长期静脉输注钙拮抗剂维拉帕米得以稳定病情，在适当监测下，该药物耐受性良好。我们认为，输注维拉帕米可能在此类患者的治疗中发挥重要作用，进一步的研究是有必要的。
