Iberti T J, Benjamin E, Paluch T A, Gentili D R, Gabrielson G V
Crit Care Med. 1986 Apr;14(4):283-4. doi: 10.1097/00003246-198604000-00006.
The effects of constant-infusion verapamil were studied in ten postoperative ICU patients who developed supraventricular tachycardia (atrial fibrillation) with rapid ventricular response rates. A 5-mg iv bolus dose of verapamil was followed by a 5-mg/h infusion that continued for 8 h. Ventricular rates were significantly (p less than .005) reduced from a pretreatment mean of 156 +/- 14 (SD) to 104 +/- 9 beat/min on constant-infusion therapy. This therapy was well tolerated without observed side-effects. Moreover, constant-infusion verapamil might avoid the hypotension and wide range of ventricular rates frequently encountered with repeated bolus doses of verapamil.
对10名术后重症监护病房（ICU）中出现伴有快速心室反应率的室上性心动过速（房颤）的患者，研究了持续静脉输注维拉帕米的效果。先静脉推注5mg维拉帕米，随后以5mg/h的速度持续输注8小时。持续输注治疗期间，心室率从治疗前的平均156±14（标准差）显著（p<0.005）降至104±9次/分钟。该治疗耐受性良好，未观察到副作用。此外，持续静脉输注维拉帕米可能避免了重复静脉推注维拉帕米时常见的低血压和心室率大幅度波动。
