Department of Translational Biomedicine and Neuroscience, University of Bari, Bari, Italy.
Department of Mental Health, ASL Bari, Bari, Italy.
Adv Neurobiol. 2024;40:143-156. doi: 10.1007/978-3-031-69491-2_6.
Magnetoencephalography (MEG) is a neuroimaging technique that has excellent temporal as well as good spatial resolution for measuring neural activity and has been extensively employed in cognitive neuroscience. However, MEG has only been more recently applied to investigations of brain networks and biomarkers in psychiatry. Besides providing new insights into the pathophysiology of major psychiatry syndromes, especially in schizophrenia, a major objective of current research is the identification of biomarkers that could inform early intervention and novel treatments. This chapter will provide a state-of-the-art overview of MEG as applied to schizophrenia, autism spectrum disorders, and Alzheimer's disease, summarizing methodological approaches and studies investigating alterations during resting-state and task-related paradigms. In addition, we will highlight future methodological developments and their potential for applications of MEG in psychiatry.
脑磁图（MEG）是一种神经影像学技术，在测量神经活动方面具有出色的时间分辨率和良好的空间分辨率，已广泛应用于认知神经科学。然而，MEG 直到最近才被应用于精神医学领域的脑网络和生物标志物研究。除了为主要精神科综合征（尤其是精神分裂症）的病理生理学提供新的见解外，当前研究的主要目标是确定能够提供早期干预和新治疗方法信息的生物标志物。本章将提供一个有关 MEG 在精神分裂症、自闭症谱系障碍和阿尔茨海默病中的应用的最新概述，总结了用于研究静息状态和任务相关范式期间变化的方法学方法和研究。此外，我们还将强调未来的方法学发展及其在精神医学中应用 MEG 的潜力。
