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光泵磁强计（OPM-MEG）磁共振脑磁图：新一代功能神经影像学。

Magnetoencephalography with optically pumped magnetometers (OPM-MEG): the next generation of functional neuroimaging.

机构信息

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

出版信息

Trends Neurosci. 2022 Aug;45(8):621-634. doi: 10.1016/j.tins.2022.05.008. Epub 2022 Jun 30.

DOI:10.1016/j.tins.2022.05.008
PMID:35779970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10465236/
Abstract

Magnetoencephalography (MEG) measures human brain function via assessment of the magnetic fields generated by electrical activity in neurons. Despite providing high-quality spatiotemporal maps of electrophysiological activity, current MEG instrumentation is limited by cumbersome field sensing technologies, resulting in major barriers to utility. Here, we review a new generation of MEG technology that is beginning to lift many of these barriers. By exploiting quantum sensors, known as optically pumped magnetometers (OPMs), 'OPM-MEG' has the potential to dramatically outperform the current state of the art, promising enhanced data quality (better sensitivity and spatial resolution), adaptability to any head size/shape (from babies to adults), motion robustness (participants can move freely during scanning), and a less complex imaging platform (without reliance on cryogenics). We discuss the current state of this emerging technique and describe its far-reaching implications for neuroscience.

摘要

脑磁图（MEG）通过评估神经元电活动产生的磁场来测量人类大脑功能。尽管可以提供高质量的电生理活动时空图谱，但当前的 MEG 仪器受到繁琐的场传感技术的限制，导致实用性存在重大障碍。在这里，我们回顾了新一代的 MEG 技术，这些技术开始克服许多这些障碍。通过利用量子传感器，即光泵磁强计（OPM），“OPM-MEG”有可能显著优于当前的技术水平，有望提高数据质量（更好的灵敏度和空间分辨率）、适应任何头部大小/形状（从婴儿到成人）、运动稳健性（参与者可以在扫描过程中自由移动）以及更简单的成像平台（无需依赖低温技术）。我们讨论了这项新兴技术的现状，并描述了它对神经科学的深远影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e41/10465236/4ecd4d0ce47b/nihms-1924480-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e41/10465236/80c0265429f9/nihms-1924480-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e41/10465236/7cd4c5d15492/nihms-1924480-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e41/10465236/4f1001e7d8ff/nihms-1924480-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e41/10465236/45c9e2c4f7ea/nihms-1924480-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e41/10465236/4ecd4d0ce47b/nihms-1924480-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e41/10465236/80c0265429f9/nihms-1924480-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e41/10465236/7cd4c5d15492/nihms-1924480-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e41/10465236/4f1001e7d8ff/nihms-1924480-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e41/10465236/45c9e2c4f7ea/nihms-1924480-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e41/10465236/4ecd4d0ce47b/nihms-1924480-f0005.jpg

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Sci Rep. 2022 Oct 26;12(1):17993. doi: 10.1038/s41598-022-21870-5.
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On-scalp magnetocorticography with optically pumped magnetometers: Simulated performance in resolving simultaneous sources.
Imaging Neurosci (Camb). 2025 Mar 13;3. doi: 10.1162/imag_a_00489. eCollection 2025.
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Demonstrating equivalence across magnetoencephalography scanner platforms using neural fingerprinting.使用神经指纹识别技术证明不同脑磁图扫描仪平台之间的等效性。
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Source reconstruction without an MRI using optically pumped magnetometer-based magnetoencephalography.使用基于光泵磁力仪的脑磁图在无磁共振成像（MRI）的情况下进行源重建。
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Determining sensor geometry and gain in a wearable MEG system.确定可穿戴式脑磁图（MEG）系统中的传感器几何形状和增益。
Imaging Neurosci (Camb). 2025 Apr 8;3. doi: 10.1162/imag_a_00535. eCollection 2025.
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Inferring laminar origins of MEG signals with optically pumped magnetometers (OPMs): A simulation study.利用光泵磁力仪（OPM）推断脑磁图（MEG）信号的层状起源：一项模拟研究。
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Optimising the sensitivity of optically-pumped magnetometer magnetoencephalography to gamma band electrophysiological activity.优化光泵磁力计脑磁图对伽马波段电生理活动的敏感性。
Imaging Neurosci (Camb). 2024 Mar 19;2. doi: 10.1162/imag_a_00112. eCollection 2024.
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