State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
NPJ Biofilms Microbiomes. 2024 Nov 19;10(1):130. doi: 10.1038/s41522-024-00607-4.
The "gut-brain axis" is involved in many physiological processes. However, its role in regulating mammary gland (MG) development remains unknown. In this study, we established the mice model of bilateral subdiaphragmatic vagotomy (Vago) to clarify the effects of "gut-brain axis" on MG development in pubertal mice. The results showed that Vago reduced the ratio of Lactobacillus and Bifidobacterium, neuronal excitability in the nucleus of solitary tract (NTS), and synthesis and secretion of BDNF, thereby slowing MG development. Transplanting the gut microbiota of Vago mice to recipient mice replicated these effects, and transplanting the gut microbiota of Control mice to Vago mice did not alleviate these effects. Galacto-Oligosaccharide (GOS), which up-regulates the ratio of Lactobacillus and Bifidobacterium, supplementation elevated NTS neuron excitability, synthesis and secretion of BDNF, and MG development, but Vago reversed these benefits. In conclusion, GOS enhances BDNF-mediated mammary gland development in pubertal mice via the "gut-brain axis".
“肠脑轴”参与许多生理过程。然而，其在调节乳腺（MG）发育中的作用尚不清楚。在本研究中，我们建立了双侧膈下迷走神经切断术（Vago）的小鼠模型，以阐明“肠脑轴”对青春期小鼠 MG 发育的影响。结果表明，Vago 降低了乳酸杆菌和双歧杆菌的比例、孤束核（NTS）中的神经元兴奋性以及 BDNF 的合成和分泌，从而减缓 MG 发育。将 Vago 小鼠的肠道微生物群移植到受体小鼠中复制了这些效果，而将对照小鼠的肠道微生物群移植到 Vago 小鼠中则没有减轻这些效果。半乳糖低聚糖（GOS）可上调乳酸杆菌和双歧杆菌的比例，补充 GOS 可提高 NTS 神经元兴奋性、BDNF 的合成和分泌以及 MG 发育，但 Vago 逆转了这些作用。总之，GOS 通过“肠脑轴”增强了青春期小鼠中 BDNF 介导的乳腺发育。
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