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队列研究概况:一组韩国原子弹幸存者及其后代

Cohort study profile: a cohort of Korean atomic bomb survivors and their offspring.

作者信息

Lee Hamin, Nam Jin-Wu, Kim Mi Kyung, Kim Inah, Kim Yu-Mi, Park Boyoung

机构信息

Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.

Department of Life Science, Hanyang University College of Natural Sciences, Seoul, Korea.

出版信息

Epidemiol Health. 2024;46:e2024089. doi: 10.4178/epih.e2024089. Epub 2024 Nov 18.

Abstract

The Korean Atomic Bomb Survivor Cohort (K-ABC) study was designed to investigate the health impacts of atomic bomb exposure on Korean survivors and to explore whether these effects are passed down genetically to their descendants. This paper outlines the study's design, data collection methods, baseline socio-demographic characteristics, exposure status, and disease prevalence among the participants, based on survey responses and health examinations. From 2020 to 2024, a total of 2,544 individuals, comprising 1,109 atomic bomb survivors (G1), 1,193 children of G1 (G2), and 242 grandchildren of G1 (G3), consented to participate in the study. Of these, 1,828 participants (659 in G1, 927 in G2, and 242 in G3) completed the survey and underwent health examinations, representing a participation rate of 71.9%. Exposure information was gathered using a questionnaire and verified through records from the Korean Red Cross and a handbook issued by the Japanese government. Disease prevalence was determined based on participants' self-reported physician diagnoses. This study presents details about the K-ABC study and provides baseline data on the participants recruited. These data will be valuable for interpreting the results of future K-ABC studies.

摘要

韩国原子弹爆炸幸存者队列(K-ABC)研究旨在调查原子弹爆炸对韩国幸存者的健康影响,并探讨这些影响是否会通过基因遗传给他们的后代。本文基于调查回复和健康检查,概述了该研究的设计、数据收集方法、参与者的基线社会人口特征、暴露状况和疾病患病率。2020年至2024年期间,共有2544人同意参与该研究,其中包括1109名原子弹爆炸幸存者(G1)、1193名G1的子女(G2)和242名G1的孙辈(G3)。其中,1828名参与者(G1中有659人,G2中有927人,G3中有242人)完成了调查并接受了健康检查,参与率为71.9%。暴露信息通过问卷调查收集,并通过韩国红十字会的记录和日本政府发布的手册进行核实。疾病患病率根据参与者自我报告的医生诊断确定。本研究介绍了K-ABC研究的详细情况,并提供了所招募参与者的基线数据。这些数据对于解释未来K-ABC研究的结果将具有重要价值。

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