King's College Hospital, London, England.
Department of Radiology, Hilla University College, Babylon, Iraq.
Radiat Oncol. 2024 Nov 19;19(1):164. doi: 10.1186/s13014-024-02507-5.
The present study aimed to evaluate the use of F-2-[F]-fluoro-2-deoxy-d-glucose (FDG) PET/MRI (Positron emission tomography-computed tomography) in predicting the pathological response to neoadjuvant chemotherapy (NAC) in patients with breast cancer (BC) compared to the use of MRI (Magnetic Resonance Imaging) alone.
We searched numerous databases, including PubMed, Scopus, Embase, and Science Direct, using curated keywords. The variance of each study was determined using the binomial distribution, and STATA version 14 was used to analyze the data by performing random-effect models. Additionally, we calculated study heterogeneity using the chi-squared test and I index and utilized funnel plots and Egger tests to assess publication bias.
The current investigation analyzed 239 patients from six published studies. The pooled estimated sensitivity and specificity of F-FDG PET/MRI was 0.91 (95% CI = 0.90 to 0.92, I = 100% and P = 0.000) and 0.62 (95% CI = 0.53 to 0.72, I = 99.8% and P = 0.000), respectively. Pooled sensitivity and specificity of MRI were 0.78 (95%CI = 0.59 to 0.96, I = 100% and P = 0.000) and 0.56 (95%CI = 0.33 to 0.80, I = 99.8% and P = 0.000), respectively.
Based on our findings, the combined form of F-FDG PET/MRI imaging is more sensitive and specific than MRI alone for predicting response to NAC in BC patients.
本研究旨在评估 F-2-[F]-氟代-2-脱氧-D-葡萄糖（FDG）正电子发射断层扫描-计算机断层扫描（PET/CT）联合磁共振成像（MRI）在预测乳腺癌（BC）患者新辅助化疗（NAC）病理反应方面的应用，与单独使用 MRI 相比。
我们使用已编制好的关键词在包括 PubMed、Scopus、Embase 和 Science Direct 在内的多个数据库中进行了搜索。使用二项式分布确定每个研究的方差，使用 STATA 版本 14 通过执行随机效应模型对数据进行分析。此外，我们使用卡方检验和 I 指数评估研究异质性，并使用漏斗图和 Egger 检验评估发表偏倚。
本研究共分析了来自 6 项已发表研究的 239 名患者。FDG PET/MRI 的汇总估计敏感性和特异性为 0.91（95%置信区间 [CI] = 0.90 至 0.92，I = 100%，P = 0.000）和 0.62（95%CI = 0.53 至 0.72，I = 99.8%，P = 0.000）。MRI 的汇总敏感性和特异性分别为 0.78（95%CI = 0.59 至 0.96，I = 100%，P = 0.000）和 0.56（95%CI = 0.33 至 0.80，I = 99.8%，P = 0.000）。
根据我们的发现，FDG PET/MRI 联合成像比单独使用 MRI 更敏感和特异，可用于预测 BC 患者对 NAC 的反应。
