Oraby Mohammed I, Haddad Manar M, Nasser Mona, Hussein Mona
Department of Neurology, Beni-Suef University, Beni-Suef, Egypt.
Department of Clinical and Chemical pathology, Beni-Suef University, Beni-Suef, Egypt.
Thromb J. 2024 Nov 19;22(1):103. doi: 10.1186/s12959-024-00654-z.
The relationship between venous thromboembolism and both insulin resistance and metabolic syndrome is still a matter of debate. The objective of this work was to investigate the possible association between cerebral venous sinus thrombosis (CVST) and both insulin resistance and metabolic syndrome. We aimed also to assess micro-RNA-122 serum levels in patients with CVST in comparison to controls.
This case-control study was conducted on patients having a clinical and neuroimaging diagnosis of acute CVST (within 1 week from the onset). Patients with inconclusive brain imaging, those with a history of malignancy, diabetic patients, and patients on drugs known to affect the insulin sensitivity or lipid profile were excluded from the study. Metabolic syndrome in the included cases and controls was evaluated by measuring waist circumference and blood pressure in addition to assessment of Triglycerides, HDL, and fasting blood sugar. The state of insulin resistance was established if the Homeostasis model assessment-insulin resistance (HOMA-IR) value > 2.5. Serum micro-RNA-122 serum level was measured for both patients and controls.
In the present study, 36 cases diagnosed as having CVST and 34 age & sex matched controls were included. There were statistically significant differences between patients with CVST and controls regarding BMI, waist circumference, TG, fasting glucose, fasting insulin & HOMA- IR (P-value = 0.002, 0.001, 0.004, 0.003, 0.021, 0.008 respectively). There was no statistically significant difference between patients with CVST and controls regarding micro-RNA-122 serum level (P-value = 0.376), whereas CVST patients with insulin resistance had a significantly higher micro-RNA-122 serum level in comparison to those without (P-value < 0.001). Patients with CVST had a significantly higher frequency of both metabolic syndrome and insulin resistance in comparison to controls (P-value = 0.008, 0.002 respectively).
There is a significant association between CVST and both insulin resistance and metabolic syndrome.
静脉血栓栓塞与胰岛素抵抗和代谢综合征之间的关系仍存在争议。本研究的目的是探讨脑静脉窦血栓形成（CVST）与胰岛素抵抗和代谢综合征之间可能存在的关联。我们还旨在评估CVST患者与对照组相比血清微小RNA-122的水平。
本病例对照研究针对临床和神经影像学诊断为急性CVST（发病1周内）的患者进行。脑成像结果不明确的患者、有恶性肿瘤病史的患者、糖尿病患者以及正在服用已知会影响胰岛素敏感性或血脂谱药物的患者被排除在研究之外。通过测量腰围和血压，以及评估甘油三酯、高密度脂蛋白和空腹血糖，对纳入的病例和对照进行代谢综合征评估。如果稳态模型评估-胰岛素抵抗（HOMA-IR）值>2.5，则确定存在胰岛素抵抗状态。对患者和对照均测量血清微小RNA-122水平。
在本研究中，纳入了36例诊断为CVST的病例和34例年龄及性别匹配的对照。CVST患者与对照在体重指数、腰围、甘油三酯、空腹血糖、空腹胰岛素和HOMA-IR方面存在统计学显著差异（P值分别为0.002、0.001、0.004、0.003、0.021、0.008）。CVST患者与对照在血清微小RNA-122水平方面无统计学显著差异（P值=0.376），而有胰岛素抵抗的CVST患者与无胰岛素抵抗的患者相比，血清微小RNA-122水平显著更高（P值<0.001）。与对照相比，CVST患者代谢综合征和胰岛素抵抗的发生率显著更高（P值分别为0.008、0.002）。
CVST与胰岛素抵抗和代谢综合征之间存在显著关联。
