Department of Neurology, Beni-Suef University, Beni-Suef, Egypt.
Department of Neurology, Cairo University, Cairo, Egypt.
BMC Neurol. 2022 Nov 12;22(1):422. doi: 10.1186/s12883-022-02966-x.
BACKGROUND & OBJECTIVES: Studying comorbidities with migraine aids in a better understanding of its pathophysiology and potential therapeutic targets. This case-control study aimed to study the impact of insulin resistance and metabolic syndrome on the characteristics of migraine headache attacks.
A case-control study was conducted on 30 migraine patients and 30 healthy controls. The following data were assessed in migraine patients: type of migraine, duration of attacks, Migraine Severity Scale (MIGSEV), and Headache Impact Test-6 (HIT-6). Both groups were assessed for waist circumference and underwent the following tests: fasting blood glucose, fasting insulin, high-density lipoprotein cholesterol level, and triglycerides, and homeostasis model assessment-insulin resistance (HOMA-IR) was applied.
This study included age and sex-matched patients and controls. Migraine patients had significantly higher waist circumference, higher mean values of serum insulin, HOMA-IR and higher frequency of insulin resistance and metabolic syndrome than the control group (P-value = 0.005, 0.049, 0.01, 0.012, 0.024, respectively). Migraine patients with insulin resistance had significantly higher intensity and tolerability scores, MIGSEV total score, and HIT-6 total score compared to those without (P-value = 0.005, 0.005, 0.002, 0.018, respectively). There was a significantly positive correlation between the MIGSEV and HIT-6 scores and fasting insulin levels, and HOMA-IR value (P-value = 0.006, ≤ 0.001, 0.017, ≤ 0.001, respectively).
Insulin resistance and metabolic syndrome are more common in migraine patients than in healthy controls. The severity and impact of migraine attacks are higher in patients with insulin resistance than in those without.
研究偏头痛的合并症有助于更好地了解其病理生理学和潜在的治疗靶点。本病例对照研究旨在研究胰岛素抵抗和代谢综合征对偏头痛发作特征的影响。
对 30 例偏头痛患者和 30 例健康对照者进行病例对照研究。评估偏头痛患者的以下数据：偏头痛类型、发作持续时间、偏头痛严重程度量表（MIGSEV）和头痛影响测试-6（HIT-6）。对两组患者进行腰围评估，并进行以下检查：空腹血糖、空腹胰岛素、高密度脂蛋白胆固醇水平和甘油三酯，应用稳态模型评估-胰岛素抵抗（HOMA-IR）。
本研究纳入了年龄和性别匹配的患者和对照组。偏头痛患者的腰围显著较高，血清胰岛素、HOMA-IR 的平均值以及胰岛素抵抗和代谢综合征的发生率均显著高于对照组（P 值分别为 0.005、0.049、0.01、0.012、0.024）。与无胰岛素抵抗的偏头痛患者相比，有胰岛素抵抗的偏头痛患者的强度和耐受性评分、MIGSEV 总分和 HIT-6 总分均显著更高（P 值分别为 0.005、0.005、0.002、0.018）。MIGSEV 和 HIT-6 评分与空腹胰岛素水平和 HOMA-IR 值呈显著正相关（P 值分别为 0.006、≤0.001、0.017、≤0.001）。
与健康对照组相比，偏头痛患者中胰岛素抵抗和代谢综合征更为常见。与无胰岛素抵抗的偏头痛患者相比，有胰岛素抵抗的偏头痛患者的偏头痛发作严重程度和影响更高。
